Results 121 to 130 of about 7,496,605 (313)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Pacific co-operator.

, 1913
Published by, : Pacific Co-operative League.Published by, Aug. 1913- : Co-operative Publishing Company.Official organ for the Farmers' Co-operative Educational Union of America, California Division, and the Rochdale Co-operative Societies of California ...
Rochdale Co-operative Societies of California., Pacific Co-operative League.   +1 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Co-infections with Plasmodium falciparum, Schistosoma mansoni and intestinal helminths among schoolchildren in endemic areas of northwestern Tanzania. [PDF]

, 2010
Malaria, schistosomiasis and intestinal helminth infections are causes of high morbidity in most tropical parts of the world. Even though these infections often co-exist, most studies focus on individual diseases.
Jorg Heukelbach, Mazigo, Humphrey D., Zinga Maria, Heukelbach Jorg, Mahande Aneth M, Mshana, Stephen E., Rebecca Waihenya, Mazigo, Humphrey D, Seni, Jeremiah, Mkoji, Gerald M, Kapesa Anthony, Mazigo Humphrey D, Nicholas JS Lwambo, Mnyone, Ladislaus L, Kweka, Eliningaya J, Mnyone, Ladislaus L ., Waihenya, Rebecca, Mshana, Stephen E, Seni Jeremiah, Kweka, Eliningaya J., Maria Zinga, Anthony Kapesa, Heukelbach, Jorg, Lwambo, Nicholas J.S., Stephen E Mshana, Lwambo, Nicholas Js, Aneth M Mahande, Zinga, Maria, Eliningaya J Kweka, Mshana Stephen E, Ladislaus L Mnyone, Mkoji, Gerald M., Kweka Eliningaya J, Lwambo Nicholas JS, Mahande, Aneth M ., Mkoji Gerald M, Jeremiah Seni, Mahande, Aneth M, Gerald M Mkoji, Kapesa, Anthony, Mnyone Ladislaus L, Waihenya Rebecca, Humphrey D Mazigo   +42 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Absence of human metapneumovirus co-infection in cases of severe respiratory syncytial virus infection

, 2006
It has been suggested that co-infection of human metapneumovirus (hMPV) in severe respiratory syncytial (RSV) virus bronchiolitis is very common. To evaluate the epidemiology of hMPV co-infection in children with severe lower respiratory tract infection ...
Rossen, J W A; id_orcid, Rossen, J W A, van Woensel, J B M, Lutter, R., Rossen, J. W. A., J.B.M. van Woensel, Lutter, R, Bos, A P, J.W.A. Rossen, Bos, A. P., Schuurman, R., van Woensel, J. B. M., A.P. Bos, R. Lutter, R. Schuurman, Schuurman, R   +15 more
core   +1 more source