Results 61 to 70 of about 7,496,605 (313)

Comparison of targeted next-generation sequencing and conventional tests for pathogen detection in community-acquired and severe community-acquired pneumonia: a retrospective cohort study

Frontiers in Microbiology
BackgroundCommunity-acquired pneumonia (CAP) and severe community-acquired pneumonia (sCAP) impose a significant burden on the healthcare system. As a more severe form of CAP, sCAP is associated with a higher mortality rate, and patients frequently ...
Feng Wang, Axiang Han, Wanting Hong, Ying Mao, Weijie Sun, Yixuan Hu, Lingling Lu   +6 more
doaj   +1 more source

The mechanisms of action of Plasmodium infection against cancer

Cell Communication and Signaling, 2021
Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumor angiogenesis, inhibits tumor growth and ...
Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah   +3 more
doaj   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Discriminative Index: A Novel Indicator for Evaluating Machine Learning Algorithms in Laboratory Medicine

Diagnostics
Background: Machine learning models are increasingly applied in clinical practice. However, conventional performance metrics such as sensitivity, specificity, and accuracy do not capture the structural characteristics of predictive probability ...
Hsin-Yao Wang, Wan-Ying Lin, Martin Spüler, Sven Brand, Jia-Ruei Yu, Markus Kostrzewa   +5 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

HIV and Co-Infections: Updates and Insights

Viruses, 2023
Co-infections are frequent in HIV patients; some of them may be AIDS-defining, while others share the same underlying virus mechanism [...]
Francesco Di Gennaro, Alessandra Vergori, Davide Fiore Bavaro   +2 more
openaire   +4 more sources

Immune factors produced by PBMCs upon stimulation with lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1-derived exopolysaccharides inhibit HCoV-229E and SARS-CoV-2 replication

Scientific Reports
The COVID-19 pandemic entered a controllable phase due to vaccine and drug development. The development of defense strategies of enhancing host innate immunity remains imperative to counter the emergence of infectious SARS-CoV-2 variants.
Shuyi Tang, Reiko Takai-Todaka, Shoko Ishii, Hiroki Kono, Reiko Watanabe, Miho Ogawa, Hiroshi Kano, Kazuhiko Katayama, Toshihiro Sashihara, Kenichi Hojo, Kei Haga   +10 more
doaj   +1 more source

Barriers Preventing Liver Transplantation in Canadians with HIV Infection – Perceptions of HIV Specialists

Canadian Journal of Gastroenterology, 2007
Liver transplantation is a life-saving procedure with demonstrated utility. There are accumulating data indicating that this procedure is helpful in HIV-infected patients as well.
Curtis L Cooper, Joanne DeForest, John Gill, Richard Lalonde, on behalf of the Canadian HIV Trials Network (CTN) Co-Infection Core Group   +4 more
doaj   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study. [PDF]

, 2007
OBJECTIVES: To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and maintaining the cohort ...
Abdool Karim Salim S., Grobler Anneke, Anneke Grobler, Mlisana, Koleka Patience., Clive M Gray, Iriogbe, Itua, CAPRISA 002 Acute Infection Study Team, van Loggerenberg, F, Quarraisha Abdool Karim, Gray, Clive M., Mlisana, K, Barnabas Nomampondo, Mlisana, Koleka, Abdool Karim, Salim Safurdeen., Grobler, A, Williamson, Carolyn., Abdool Karim, Quarraisha, Francois van Loggerenberg, Barnabas, Nomampondo, Nomampondo Barnabas, Williamson Carolyn, Barnabas, N, Sara C Auld, Karim, SSA, Williamson, Carolyn, Williamson, C, Abdool Karim, Quarraisha., van Loggerenberg Francois, Koleka Mlisana, Lynn Morris, Gray, Clive M, van Loggerenberg, Francois, Auld, Sara C, Auld Sara C., Karim, QA, Morris, Lynn, Gray Clive M., Grobler, Anneke, Morris, Lynn., Auld, Sara C., Itua Iriogbe, Iriogbe, Itua., Salim S Abdool Karim, Morris Lynn, Auld, SC, Gray, CM, Carolyn Williamson, Abdool Karim, Salim S, Iriogbe, I, Karim, Quarraisha Abdool, Morris, L, Grobler, Anna Christina., van Loggerenberg, Francois., Iriogbe Itua, Mlisana Koleka, Abdool Karim Quarraisha, Barnabas, Nomampondo.   +56 more
core   +1 more source