Results 41 to 50 of about 1,159,470 (267)

Molecular mechanisms of co-infections

EMBO Reports
Abstract Co-infections generally cause exacerbated pathologies in patients, yet a knowledge gap between clinical data and the underlying molecular mechanisms remains. Clinical studies focus on patient outcome, but much less is known about molecular mechanisms and convergence points that define the interaction between different ...
Philipp Darius Konstantin Walch, Petr Broz   +1 more
openaire   +3 more sources

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Discriminative Index: A Novel Indicator for Evaluating Machine Learning Algorithms in Laboratory Medicine

Diagnostics
Background: Machine learning models are increasingly applied in clinical practice. However, conventional performance metrics such as sensitivity, specificity, and accuracy do not capture the structural characteristics of predictive probability ...
Hsin-Yao Wang, Wan-Ying Lin, Martin Spüler, Sven Brand, Jia-Ruei Yu, Markus Kostrzewa   +5 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Immune factors produced by PBMCs upon stimulation with lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1-derived exopolysaccharides inhibit HCoV-229E and SARS-CoV-2 replication

Scientific Reports
The COVID-19 pandemic entered a controllable phase due to vaccine and drug development. The development of defense strategies of enhancing host innate immunity remains imperative to counter the emergence of infectious SARS-CoV-2 variants.
Shuyi Tang, Reiko Takai-Todaka, Shoko Ishii, Hiroki Kono, Reiko Watanabe, Miho Ogawa, Hiroshi Kano, Kazuhiko Katayama, Toshihiro Sashihara, Kenichi Hojo, Kei Haga   +10 more
doaj   +1 more source

Barriers Preventing Liver Transplantation in Canadians with HIV Infection – Perceptions of HIV Specialists

Canadian Journal of Gastroenterology, 2007
Liver transplantation is a life-saving procedure with demonstrated utility. There are accumulating data indicating that this procedure is helpful in HIV-infected patients as well.
Curtis L Cooper, Joanne DeForest, John Gill, Richard Lalonde, on behalf of the Canadian HIV Trials Network (CTN) Co-Infection Core Group   +4 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Co-infection by Soil-Borne Fungal Pathogens Alters Disease Responses Among Diverse Alfalfa Varieties

Frontiers in Microbiology, 2021
Fusarium oxysporum f. sp. medicaginis (Fom) and Rhizoctonia solani (Rs) are the major soil-borne fungal pathogens that pose severe threats to commercial alfalfa production in China.
Xiangling Fang, Caixia Zhang, Zi Wang, Tingyu Duan, Binhua Yu, Xitao Jia, Jiayin Pang, Lisong Ma, Yanrong Wang, Zhibiao Nan   +9 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction

Journal of Inflammation Research, 2015
Amrita DosanjhDepartment of Pediatrics, Rady Children’s Hospital, San Diego, CA, USABackground: Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at
Dosanjh A
doaj