Results 21 to 30 of about 1,164,458 (219)

Investigating the Prevalence of Mycobacterium Tuberculosis in Patientsinfected with HIV Microscopically and Molecularly [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background & aim: One of the global challenges regarding HIV patients is the increased sensitivity to intracellular pathogens such as tuberculosis. CD4+ cells are the main defense element against Mycobacterium tuberculosis, but in these people, as their ...
A Kasavandi, F Foroohi, T Rahimi, A Ferdousi, T Mohammadian   +4 more
doaj  

The mechanisms of action of Plasmodium infection against cancer

Cell Communication and Signaling, 2021
Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumor angiogenesis, inhibits tumor growth and ...
Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah   +3 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

Comparison of targeted next-generation sequencing and conventional tests for pathogen detection in community-acquired and severe community-acquired pneumonia: a retrospective cohort study

Frontiers in Microbiology
BackgroundCommunity-acquired pneumonia (CAP) and severe community-acquired pneumonia (sCAP) impose a significant burden on the healthcare system. As a more severe form of CAP, sCAP is associated with a higher mortality rate, and patients frequently ...
Feng Wang, Axiang Han, Wanting Hong, Ying Mao, Weijie Sun, Yixuan Hu, Lingling Lu   +6 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Discriminative Index: A Novel Indicator for Evaluating Machine Learning Algorithms in Laboratory Medicine

Diagnostics
Background: Machine learning models are increasingly applied in clinical practice. However, conventional performance metrics such as sensitivity, specificity, and accuracy do not capture the structural characteristics of predictive probability ...
Hsin-Yao Wang, Wan-Ying Lin, Martin Spüler, Sven Brand, Jia-Ruei Yu, Markus Kostrzewa   +5 more
doaj   +1 more source

Barriers Preventing Liver Transplantation in Canadians with HIV Infection – Perceptions of HIV Specialists

Canadian Journal of Gastroenterology, 2007
Liver transplantation is a life-saving procedure with demonstrated utility. There are accumulating data indicating that this procedure is helpful in HIV-infected patients as well.
Curtis L Cooper, Joanne DeForest, John Gill, Richard Lalonde, on behalf of the Canadian HIV Trials Network (CTN) Co-Infection Core Group   +4 more
doaj   +1 more source

BMT4me En Español: Multisite Feasibility and Usability Testing of a Spanish‐Language mHealth Adherence Support App for Spanish‐Speaking Caregivers of Children After Hematopoietic Stem Cell Transplantation and Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Medication nonadherence during the first 100 days after pediatric hematopoietic stem cell transplantation (HSCT) and during oncology treatment increases risk for complications. BMT4me is a caregiver‐facing mobile health (mHealth) application providing medication reminders, symptom tracking, and note‐taking features to support ...
Micah A. Skeens, Madeline R. Peek, Bianca Franklin, Emre Sezgin, Melissa Beauchemin   +4 more
wiley   +1 more source

Immune factors produced by PBMCs upon stimulation with lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1-derived exopolysaccharides inhibit HCoV-229E and SARS-CoV-2 replication

Scientific Reports
The COVID-19 pandemic entered a controllable phase due to vaccine and drug development. The development of defense strategies of enhancing host innate immunity remains imperative to counter the emergence of infectious SARS-CoV-2 variants.
Shuyi Tang, Reiko Takai-Todaka, Shoko Ishii, Hiroki Kono, Reiko Watanabe, Miho Ogawa, Hiroshi Kano, Kazuhiko Katayama, Toshihiro Sashihara, Kenichi Hojo, Kei Haga   +10 more
doaj   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source