Results 11 to 20 of about 1,164,458 (219)

Engineered Salmonella enterica serovar Typhimurium overcomes limitations of anti-bacterial immunity in bacteria-mediated tumor therapy

OncoImmunology, 2018
Cancer is one of the leading causes of death in the industrialized world and represents a tremendous social and economic burden. As conventional therapies fail to provide a sustainable cure for most cancer patients, the emerging unique immune therapeutic
Sebastian Felgner, Dino Kocijancic, Michael Frahm, Ulrike Heise, Manfred Rohde, Kurt Zimmermann, Christine Falk, Marc Erhardt, Siegfried Weiss   +8 more
doaj   +1 more source

Treatment of biofilms in bacterial vaginosis by an amphoteric tenside pessary-clinical study and microbiota analysis

Microbiome, 2017
Background Bacterial vaginosis (BV) is the most common vaginal syndrome among women in their reproductive years. It is associated with an increased risk of acquiring sexually transmitted infections and complications like preterm labor.
Cornelia Gottschick, Zhi-Luo Deng, Marius Vital, Clarissa Masur, Christoph Abels, Dietmar H. Pieper, Manfred Rohde, Werner Mendling, Irene Wagner-Döbler   +8 more
doaj   +1 more source

Influenza Viruses: Innate Immunity and mRNA Vaccines

Frontiers in Immunology, 2021
The innate immune system represents the first line of defense against influenza viruses, which cause severe inflammation of the respiratory tract and are responsible for more than 650,000 deaths annually worldwide.
SangJoon Lee, Jin-Hyeob Ryu, Jin-Hyeob Ryu   +2 more
doaj   +1 more source

Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial

Human Vaccines & Immunotherapeutics, 2019
Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected.
Tetsuo Nakayama, Masahiro Eda, Motonori Hirano, Wakako Goto   +3 more
doaj   +1 more source

COVID‐19 co‐infection in a patient with brucellosis

Clinical Case Reports, 2022
An 89‐year‐old male case was hospitalized in the COVID‐19 department. His CT scan showed nodular opacities, also a variable low P O2, elevated transaminases, and a high D‐dimer concentration. The patient diagnosed with active brucellosis.
Shiva Shabani, Saleh Ghadimi
doaj   +1 more source

Comparative analysis of metagenomic and targeted next-generation sequencing for pathogens diagnosis in bronchoalveolar lavage fluid specimens

Frontiers in Cellular and Infection Microbiology
BackgroundAlthough the emerging NGS-based assays, metagenomic next-generation sequencing (mNGS) and targeted next-generation sequencing (tNGS), have been extensively utilized for the identification of pathogens in pulmonary infections, there have been ...
Weijie Sun, Lin Zheng, Le Kang, Chen Chen, Likai Wang, Lingling Lu, Feng Wang   +6 more
doaj   +1 more source

Novel manufacturing process of pneumococcal capsular polysaccharides using advanced sterilization methods

Frontiers in Bioengineering and Biotechnology
Pneumococcal disease is caused by Streptococcus pneumoniae, including pneumonia, meningitis and sepsis. Capsular polysaccharides (CPSs) have been shown as effective antigens to stimulate protective immunity against pneumococcal disease.
Yuelong Li, Xin Cao, Xueting Huang, Yanli Liu, Jianlong Wang, Qian Jin, Jiankai Liu, Jing-Ren Zhang, Haifa Zheng   +8 more
doaj   +1 more source

Metatranscriptome Analysis of the Vaginal Microbiota Reveals Potential Mechanisms for Protection against Metronidazole in Bacterial Vaginosis

mSphere, 2018
Bacterial vaginosis (BV) is a prevalent multifactorial disease of women in their reproductive years characterized by a shift from the Lactobacillus species-dominated microbial community toward a taxonomically diverse anaerobic community.
Zhi-Luo Deng, Cornelia Gottschick, Sabin Bhuju, Clarissa Masur, Christoph Abels, Irene Wagner-Döbler   +5 more
doaj   +1 more source

Hepatic Fibrosis Progression in HIV-Hepatitis C Virus Co-Infection--The Effect of Sex on Risk of Significant Fibrosis Measured by Aspartate-to-Platelet Ratio Index. [PDF]

PLoS ONE, 2015
In Hepatitis C virus (HCV) mono-infection, male sex is associated with faster liver fibrosis progression but the effects of sex have not been well studied in HIV-HCV co-infected patients.
Kathleen C Rollet-Kurhajec, Erica E M Moodie, Sharon Walmsley, Curtis Cooper, Neora Pick, Marina B Klein, Canadian Co-infection Cohort Study (CTN 222)   +6 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source