Results 51 to 60 of about 3,127,636 (279)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Engineering, 2015 The issues of reducing CO2 levels in the atmosphere, sustainably utilizing natural mineral resources, and dealing with industrial waste offer challenging opportunities for sustainable development in energy and the environment.
Heping Xie +7 more
doaj +1 more source
Effect of tillage practices on the soil carbon dioxide flux during fall and spring seasons in a Mediterranean Vertisol [PDF]
, 2011 In this study, we assessed the effect of conventional tillage (CT), reduced (RT) and no tillage (NT) practices on the soil CO2 flux of a Mediterranean Vertisol in semi-arid Morocco.
Corbeels, M +6 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2021 The effects of H2O and CO2 additions to n-heptane/air mixture on soot formation studied using detailed soot formation model. The simulation model is comprised of gas-phase reaction model and particle formation/growth model.
Yoshiki TAKATORI
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Effect of injection depth of digestate liquid fraction on soil carbon dioxide emission and maize biomass production [PDF]
, 2016 The aim of this study was to evaluate, in open field conditions, the effect of injection depth of digestate liquid fraction (10 cm, 25 cm and 35 cm) in clay loam soil, on CO2 emission. An un-amended soil was considered as control. The study was performed
Barbera, Antonio C. +2 more
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
The drivers of Chinese CO2 emissions from 1980 to 2030 [PDF]
, 2008 China's energy consumption doubled within the first 25 years of economic reforms initiated at the end of the 1970s, and doubled again in the past 5 years. It has resulted of a threefold CO2 emissions increase since early of 1980s.
Akimoto +45 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source