Results 81 to 90 of about 3,133,433 (280)

Worldwide distribution of continental rock lithology: Implications for the atmospheric/soil CO2 uptake by continental weathering and alkalinity river transport to the oceans [PDF]

, 2003
The silicate rock weathering followed by the formation of carbonate rocks in the ocean, transfers CO2 from the atmosphere to the lithosphere. This CO2 uptake plays a major role in the regulation of atmospheric CO2 concentrations at the geologic ...
Amiotte Suchet, Philippe, Ludwig, Wolfgang, Probst, Jean-Luc   +2 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

No way out? The double-bind in seeking global prosperity alongside mitigated climate change [PDF]

, 2012
In a prior study, I introduced a simple economic growth model designed to be consistent with general thermodynamic laws. Unlike traditional economic models, civilization is viewed only as a well-mixed global whole with no distinction made between ...
Garrett, Timothy J.
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The effect of environmental stressors on the development and behaviour of larval Oryzias latipes [PDF]

, 2020
Elevated water temperature and dissolved carbon dioxide (CO2) are two environmental stressors that freshwater organisms face in the Anthropocene. Larval fishes are particularly susceptible to elevation in water parameters, as they are often confined to ...
McIntosh, Emily
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CO2-CH4, and N2O Emissions From Oil Palm Plantation On Deep Peat as Affected by N Fertilization [PDF]

, 2012
Through drainage and nitrogen (N) fertilization, oil palm plantation on peatlands affect emission of the main greenhouse gases (GHG) - carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O).
Bonneau, Xavier, Hergoualc'h, Kristell, Indrasuara, Kooseni, P Handayani, Etik, Van Noordwijk, Meine, Verchot, Louis   +5 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Committed emissions from existing energy infrastructure jeopardize 1.5 °C climate target. [PDF]

, 2019
Net anthropogenic emissions of carbon dioxide (CO2) must approach zero by mid-century (2050) in order to stabilize the global mean temperature at the level targeted by international efforts1-5.
Caldeira, Ken, Davis, Steven J, Hong, Chaopeng, Qin, Yue, Shearer, Christine, Tong, Dan, Zhang, Qiang, Zheng, Yixuan   +7 more
core  

Seismic design of reinforced concrete frames for minimum embodied CO2 emissions [PDF]

, 2018
Optimum structural design of reinforced concrete (RC) frames has been the focus of extensive research. Typically, previous studies set economic cost as the main design objective despite the fact that RC structures are major contributors of CO2 emissions.
Mergos, P.E.
core   +1 more source