Results 91 to 100 of about 4,382,655 (302)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Enhancement of photocatalytic CO2 reduction for novel Cd0.2Zn0.8S@Ti3C2 (MXenes) nanocomposites
, 2021 In order to achieve global energy demand by sustainable energy development and grappling climate change, the ultimate plan is the reduction and conversion of carbon dioxide (CO2).
Shah, Abdul Hakim +11 more
core +1 more source
Nitrogen/oxygen dual-defects modified g-C3N4 nanosheets for boosting photocatalytic CO2 reduction
Nano ResearchWhile thermal air exfoliation is widely used to prepare graphitic carbon nitride (g-C3N4) nanosheets, the effects of calcination conditions and atmosphere on their electronic structure and photocatalytic CO2 reduction reaction (CO2RR) performance remain ...
Dongxiao Wen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The Effects of a Sudden CO2 reduction in Spain [PDF]
Spanish emissions of carbon dioxide have grown by more than 40% in 2004 with respect to 1990. This is not compatible with the EU allocation of Kyoto-mandated CO2 reduction, even taking into account that Spanish emissions are allowed to rise by 15% in ...
Miguel Rodriguez, Xavier Labandeira
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Investigating a scaled-up electrolyser for acidic electrochemical CO2 reduction to formic acid [PDF]
, 2023 openIn questo studio è stato indagato il processo di riduzione della CO2 in acido formico in ambiente acido mediante l’utilizzo di appositi elettrolizzatori.
CARLETTO, ALBERTO
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source