Results 71 to 80 of about 737,629 (313)
, 2023 Carbon dioxide (CO2) is a prominent greenhouse gas contributing significantly to global warming. To combat this issue, one strategy is the conversion of CO2 into alcohols and hydrocarbons, which can be utilized as fuels and chemical feedstocks ...
Lucas , Bandeira +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Renewable production of nylon precursors from lignin
Cell Reports SustainabilitySummary: Cyclohexanone and cyclohexanol are critical monomeric precursors in the production of nylon 6 and nylon 66, which are conventionally sourced from petroleum.
Kaile Li +9 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Ultrasonics SonochemistryHydrodynamic cavitation (HC) surge accompanied by strong swirl is widely present in fluid machinery and has become a hot topic in many engineering fields. This paper employed a two-way coupling Eulerian-Lagrangian multiscale cavitation modeling method to
Ziyang Wang +3 more
doaj +1 more source
Emerging applications of nanodiamonds in photocatalysis
Functional Diamond, 2022 As a fascinating nanocarbon photocatalytic material, nanodiamonds (NDs) have attracted more and more attention recently due to their high chemical stability, high carrier mobility, narrowing band gap, easy surface modification, and mass production.
Li-Xia Su +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Demonstration of high biomass ratio co-firing at existing coal fired boiler
Nihon Kikai Gakkai ronbunshu, 2017 There is a CO2 emission reduction method of burning woody biomass and coal, as a technical method to reduce the CO2 emission of the coal fired power plant. But a co-firing woody biomass ratio of the existing coal fired power plants gives only the 2-3% co-
Hitoshi FUKUSHIMA +2 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source