Results 81 to 90 of about 4,382,655 (302)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Reduction

, 2023
Sustainable solar fuels production through reduction of molecular CO2 using photocatalysts is an eco-friendly and dependable source of energy for the future and for controlling the global warming.
Thillai Sivakumar Natarajan, Sagayaraj, PJJ, Honnappa, B, Natarajan, TS, Karthikeyan Sekar, Adam F. Lee, Augustin, A, Prince JJ Sagayaraj, Mariyappan Shanmugam, Brahmari Honnappa, Ashil Augustin, Shanmugam, M, Karen Wilson, Lee, AF, Wilson, K, Sekar, K   +15 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Emerging Ru-Co homogeneous-heterogeneous photocatalytic CO2 reduction systems

, 2023
Ruthenium-Cobalt photocatalytic system (RCPS) is one of the most prominent candidates for integrating homocatalysis and heterocatalysis, which has recently attracted extensive research attention for photocatalytic CO2 reduction reaction (PCO2RR). In RCPS,
Zhang, Pan, Zhao, Huijun, Fu, Dong, Pang, Weiying, Zhou, Jiyu, Zhong, YuLin, Jiang, Shuaiyu, Sun, Yanli, Zhao, Kun   +8 more
core   +1 more source

Demonstration of high biomass ratio co-firing at existing coal fired boiler

Nihon Kikai Gakkai ronbunshu, 2017
There is a CO2 emission reduction method of burning woody biomass and coal, as a technical method to reduce the CO2 emission of the coal fired power plant. But a co-firing woody biomass ratio of the existing coal fired power plants gives only the 2-3% co-
Hitoshi FUKUSHIMA, Tomoyoshi KUMAGAI, Daisuke INOUE   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hydroxyl-Modified C3N4-Ni Nanosheets Enhance Photocatalytic CO2Methanation

Taiyuan Ligong Daxue xuebao
【Purposes】 In photocatalytic CO2 reduction reaction, since the electron transfer efficiencies of CH4 and CO are close and their thermodynamic properties are similar, achieving high electron selectivity for CH4 still faces significant challenges.【Methods】
XIAO Shi, ZHANG Zhiqiang, ZHENG Jingwen, XUE Jinbo   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cu2O modified ultrathin TiO2 nanosheets optimizes *COOH formation energy for highly selective photocatalytic CO2-to-CH4 conversion

Nano Research
Photocatalytic CO2 reduction to produce valuable chemicals is a promising strategy to address environmental issues and energy crisis. However, achieving high efficiency and selectivity for converting CO2 into higher-energy CH4 remains challenging due to ...
Junying Wang, Wenjiao Chang, Tingting Wu, Lei Wang   +3 more
doaj   +1 more source

Integrating Stamping Tool Temperature Effects into Early-Stage Process Design: Insights from an Industrial Benchmark [PDF]

MATEC Web of Conferences
Reducing the CO2 footprint has become a key objective in the manufacturing sector, with the automotive industry being no exception. A significant portion of a car body consists of stamped components, making the reduction of CO2 emissions in stamping ...
Insausti Lide, Barlo Alexander, Sigvant Mats, Pilthammar Johan, de Argandoña Eneko Saenz, Mendiguren Joseba   +5 more
doaj   +1 more source