Results 11 to 20 of about 637,976 (296)

Application of the thrombin generation assay in patients with antiphospholipid syndrome: A systematic review of the literature

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe antiphospholipid syndrome (APS) is classified by the presence of antiphospholipid antibodies (aPL) and thrombotic and/or adverse obstetric outcomes. The diagnosis and risk assessment of APS is challenging.
Rachel Gehlen, Rachel Gehlen, Arne Vandevelde, Arne Vandevelde, Bas de Laat, Bas de Laat, Katrien M. J. Devreese, Katrien M. J. Devreese   +7 more
doaj   +1 more source

Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2

Journal of Thrombosis and Thrombolysis, 2020
Severe coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed.
Shi-qi Yin, Ming Huang, Dengju Li, N. Tang   +3 more
semanticscholar   +1 more source

COVID-19-associated coagulopathy and disseminated intravascular coagulation

International journal of hematology, 2020
The pathology of coronavirus disease 2019 (COVID-19) is exacerbated by the progression of thrombosis, and disseminated intravascular coagulation (DIC), and cytokine storms.
H. Asakura, H. Ogawa
semanticscholar   +1 more source

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +1 more source

The Impact of COVID-19 Disease on Platelets and Coagulation

Pathobiology (Basel), 2020
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype.
G. Wool, Jonathan L Miller
semanticscholar   +1 more source

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process

Frontiers in Cardiovascular Medicine, 2022
Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai, Cuicui Bai, Joke Konings, Joke Konings, Marisa Ninivaggi, Marcus Lancé, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +8 more
doaj   +1 more source

Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65 year-old with oculocutaneous hypopigmentation and mild bleeding diathesis: The importance of recognizing a subtle phenotype

Platelets, 2018
Hermansky-Pudlak syndrome (HPS) − characterized by the distinct clinical phenotypes of both oculocutaneous albinism and mild bleeding diathesis–is caused by mutations in genes that have crucial roles in the assembly of cellular organelles (skin ...
Juliana Perez Botero, Dong Chen, Julie A. Majerus, Lea M. Coon, Rong He, Deepti M. Warad, Rajiv K. Pruthi, William L. Nichols   +7 more
doaj   +1 more source

The effect of unfractionated heparin, enoxaparin, and danaparoid on lupus anticoagulant testing: Can activated carbon eliminate false‐positive results?

Research and Practice in Thrombosis and Haemostasis, 2020
Background Heparins and heparinoids interfere with functional clotting assays used for lupus anticoagulant (LAC) detection. However, current guidelines for LAC testing do not provide clear guidance on this matter.
Pieter M.M. De Kesel, Katrien M.J. Devreese   +1 more
doaj   +1 more source

Synergistic Effect of Bypassing Agents and Sequence Identical Analogue of Emicizumab and Fibrin Clot Structure in the In Vitro Model of Hemophilia A

TH Open, 2020
Development of inhibitors to factor VIII (FVIII) occurs in approximately 30% of severe hemophilia A (HA) patients. These patients are treated with bypassing agents (activated prothrombin complex concentrate [aPCC] and recombinant activated FVII-rFVIIa ...
Yanan Zong, Aleksandra Antovic, Nida Mahmoud Hourani Soutari, Jovan Antovic, Iva Pruner   +4 more
doaj   +1 more source

Understanding and Improving Microplastics Removal during Water Treatment: Impact of Coagulation and Flocculation.

Environmental Science and Technology, 2020
The efficacy of plastic particle removal by municipal water treatment plants is currently uncertain, and the mechanisms involved in microplastics (MPs) coagulation and flocculation have only been superficially investigated. The removal of pristine versus
Mathieu Lapointe, Jeffrey M. Farner, L. M. Hernandez, N. Tufenkji   +3 more
semanticscholar   +1 more source