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Evaluation of a Point-of-Care Viscoelastic Coagulation Monitor (VCM Vet) and Thromboelastography (TEG) in Bonobos (Pan paniscus). [PDF]
J Med PrimatolRoeder MM +7 more
europepmc +1 more source
Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
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The American Journal of the Medical Sciences, 2004
Activation of the coagulation cascade during invasive infection can result in purpura fulminans, with rapid progression of tissue ischemia, or may manifest as abnormal clotting indices alone. Although severe derangements in coagulation are associated with organ dysfunction and increased mortality, the contribution of coagulopathy to the pathophysiology
Tonya, Jagneaux +2 more
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Activation of the coagulation cascade during invasive infection can result in purpura fulminans, with rapid progression of tissue ischemia, or may manifest as abnormal clotting indices alone. Although severe derangements in coagulation are associated with organ dysfunction and increased mortality, the contribution of coagulopathy to the pathophysiology
Tonya, Jagneaux +2 more
openaire +5 more sources
Perfusion, 1997
A broad range of molecular and cellular interactions contribute to various pathophysiological alterations in haemostasis. Recent studies have shown strong links between lipoproteins and coagulation factors. Findings suggest that lipoproteins play an important role in the fibrinolytic and thrombogenic mechanisms that influence the risks of patients in ...
A, Basile-Borgia, J H, Abel
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A broad range of molecular and cellular interactions contribute to various pathophysiological alterations in haemostasis. Recent studies have shown strong links between lipoproteins and coagulation factors. Findings suggest that lipoproteins play an important role in the fibrinolytic and thrombogenic mechanisms that influence the risks of patients in ...
A, Basile-Borgia, J H, Abel
openaire +2 more sources
2003
Disseminated intravascular coagulation (DIC) is a complex acquired, coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetric complications, sepsis, cancer, and trauma.
Hazelzet, Jan, Hack, CE, Groot, Ronald
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Disseminated intravascular coagulation (DIC) is a complex acquired, coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetric complications, sepsis, cancer, and trauma.
Hazelzet, Jan, Hack, CE, Groot, Ronald
openaire +3 more sources
Biochemistry (Moscow), 2002
The process of tissue factor initiated blood coagulation is discussed. Reactions of the blood coagulation cascade are propagated by complex enzymes containing a vitamin K-dependent serine protease and an accessory cofactor protein that are assembled on a membrane surface in a calcium-dependent manner.
S. Butenas, K. G. Mann, null Butenas
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The process of tissue factor initiated blood coagulation is discussed. Reactions of the blood coagulation cascade are propagated by complex enzymes containing a vitamin K-dependent serine protease and an accessory cofactor protein that are assembled on a membrane surface in a calcium-dependent manner.
S. Butenas, K. G. Mann, null Butenas
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Blood Coagulation and Coagulation Tests
Medical Clinics of North America, 1984The hemostatic mechanism has evolved to provide efficient protection from traumatic blood loss and yet maintain the blood in a fluid state in the circulation as a whole. Recent advances in biochemistry have provided both detailed understanding of hemostasis and clinically useful coagulation assays to exploit this understanding.
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Disseminated intravascular coagulation and coagulation disorders
Current Opinion in Anaesthesiology, 2004An update on recent developments in diagnosis and treatment of disseminated intravascular coagulation.Disseminated intravascular coagulation is defined as a typical disease condition with laboratory findings indicating massive coagulation activation and reduction in procoagulant capacity. Clinical syndromes associated with the condition are consumption
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The Biochemistry of Coagulation
Clinics in Laboratory Medicine, 1984This article describes the hemostatic process following vascular injury, which involves an integrated response of the blood vessel wall, blood platelets, and plasma blood clotting factors, and the way in which these processes relate to one another. A number of diagrams are presented that diagram the component processes.
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