Results 41 to 50 of about 5,615 (251)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Constrained coalition formation

, 2011
The conventional model of coalition formation considers every possible subset of agents as a potential coalition. However, in many real-world applications, there are inherent constraints on feasible coalitions: for instance, certain agents may be ...
Michalak, T, Elkind, E, Rahwan, T, Jennings, N, Faliszewski, P, Elkind, Edith, Sroka, J, Rahwan, Talal, Michalak, Tomasz, Faliszewski, Piotr, Sroka, Jacek, Wooldridge, Michael, Jennings, Nicholas, Wooldridge, M   +13 more
core   +1 more source

Cooperative games with overlapping coalitions [PDF]

, 2010
In the usual models of cooperative game theory, the outcome of a coalition formation process is either the grand coalition or a coalition structure that consists of disjoint coalitions. However, in many domains where coalitions are associated with tasks,
Edith Elkind, Elkind, E, Maria Polukarov, Chalkiadakis, G, Jennings, N, Elkind, Edith, Polukarov, Maria, Jennings, Nick, Chalkiadakis, Georgios, Markakis, E, Markakis, Evangelos, Nicholas R. Jennings, Jennings, Nick R., Georgios Chalkiadakis, Polukarov, M, Jennings, NR, Nick R. Jennings, Evangelos Markakis, Polukarov, Mariya   +18 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A hybrid algorithm for coalition structure generation

, 2012
The current state-of-the-art algorithm for optimal coalition structure generation is IDP-IP—an algorithm that combines IDP (a dynamic programming algorithm due to Rahwan and Jennings, 2008b) with IP (a tree-search algorithm due to Rahwan et al., 2009 ...
Nicholas R. Jennings, Rahwan, Talal, Jennings, Nicholas R., Talal Rahwan, Michalak, Tomasz, Tomasz Michalak   +5 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Constrained optimal grouping of cloud application components

Journal of Cloud Computing: Advances, Systems and Applications
Cloud applications are built from a set of components often deployed as containers, which can be deployed individually on separate Virtual Machines (VMs) or grouped on a smaller set of VMs.
Marta Różańska, Geir Horn
doaj   +1 more source