AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Formation of coalition structures as a non-cooperative game
Traditionally social sciences are interested in structuring people in multiple groups based on their individual preferences. This pa- per suggests an approach to this problem in the framework of a non- cooperative game theory.
Levando, Dmitry
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The NTU consistent coalitional value [PDF]
We introduce a new value for NTU games with coalition structure. This value coincides with the consistent value for trivial coalition structures, and with the Owen value for TU games with coalition structure. Furthermore, we present two characterizations:
Gustavo Bergantiños, Juan Vidal-Puga
core
Opportunities and risks of an integrated academic support : [Vortrag ; Tagung] "Integration of Information Services into University Infrastructures" - 7th Frankfurt Symposium: 12.10. - 13.10.2007 [PDF]
In the year 2000 the Deutsche Initiative für Netzwerkinformation (DINI) / German Coalition of Network Information was founded: 10 theses "Changes in information infrastructure – challenges to universities and their information and communications ...
Degkwitz, Andreas
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A Non-cooperative Foundation of Core-Stability in Positive Externality NTU-Coalition Games [PDF]
We identify the core as an appealing stability concept of cooperative game theory, but argue that the non-cooperative approach has conceptual advantages in the context of economic problems with externalities.
Bianca Rundshagen, Michael Finus
core
Market Efficiency and Coalition Structures [PDF]
We consider a three-stage game in which symmetric firms decide whether to invest in a cost-reducing technology, then they have the possibility to merge (forming coalitions), and eventually, in the third stage, a Cournot oligopoly game is played by the ...
Bartolini, David
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Coalition structures induced by the strength of a graph [PDF]
We study cooperative games associated with a communication structure which takes into account a level of communication between players. Let us consider an undirected communication graph : each node represents a player and there is an edge between two ...
Alexandre Skoda, Michel Grabisch
core

