Results 51 to 60 of about 17,734 (251)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Journal of Applied Animal Research, 2020 In recent years, different patterns of piebald/skewbald coat colour have become popular in horses. The tobiano pattern may appear in one of three forms: minimal, classic or maximal.
Marta Pasternak +3 more
doaj +1 more source
Proceedings of the Zoological Society of London, 1923 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +3 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
On the way to functional agro biodiversity: coat colour gene variability in goats
Animal, 2012 Functional agro biodiversity defines the exploitation of biodiversity to provide ecosystem services, support sustainable agricultural production and benefit the regional and global environment and the public at large (ELN-FAB, 2009; www.eln_fab.eu ...
L. Nicoloso +3 more
doaj +1 more source
Dun Coat Colour in the Horse [PDF]
Nature, 1910 MY attention has been directed to a letter in NATURE of November 24 over the signature of Prof. J. Wilson. He disputes the accuracy of certain extractions from “The General Stud Book,” which originally appeared in The Veterinary Record, in my paper on the inheritance of dun coat-colour. Prof.
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Reindeer coat colour variants in Finland
Rangifer, 2010 A research program based on reindeer coat colour had its first field survey in Finland after the calving season of May 2009. This short notice advances the main observations of the survey where, besides the wild allele, a new mutant could be identified ...
Jean J. Lauvergne, Mauri Nieminen
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source