Results 51 to 60 of about 90,378 (260)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Identification and expression analysis of PIN genes related to seed coat development in pomegranate [PDF]

Guoshu xuebao
[Objective] The auxin efflux proteins PIN-formed (PIN) is a secondary transporter protein that plays an important role in regulating auxin polarity transport during a variety of developmental processes in plants.
LI Mingxia, ZHAO Haoyu, DENG Bo, LI Jiyu, CAO Zhen, WANG Min, HUANG Yuhan, LIU Chunyan, QIN Gaihua   +8 more
doaj   +1 more source

Revision of Estimates of the Molecular Weights of Tobravirus Coat Proteins

Intervirology, 1975
The molecular weights of proteins from several tobacco rattle viruses (or tobraviruses) have been determined by electrophoresis with 'marker' proteins in acrylamide gels of different strengths. Plotting KR, a measure of the effect of varying the gel strength, against molecular weight gave a value of 23,000 +/- 2,800 for tobacco rattle virus (TRV ...
M A, Mayo, D J, Robinson
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

IAC 1850: High yielding carioca common bean cultivar

Crop Breeding and Applied Biotechnology, 2019
IAC 1850 is a common bean cultivar with a carioca (beige-colored with brown stripes) seed coat, average cycle of 88 days, semi-upright plant architecture, tolerance to seed coat darkening, 1000 seed weight of 280 grams, resistance to the main diseases in
Sérgio Augusto Morais Carbonell, Alisson Fernando Chiorato, Luiza Maria Capanema Bezerra, João Guilherme Ribeiro Gonçalves, Daiana Alves da Silva, Jose Antonio de Fatima Esteves, Luciana Lasry Benchimol-Reis, Cassia Regina Limonta Carvalho, Vera Lúcia Nishijima Paes de Barros, Rogério Soares de Freitas, Marcelo Ticelli, Paulo Boller Gallo   +11 more
doaj  

Physical and physiological characterization of heteromorphic seeds of Erythrina velutina Willd. [PDF]

Journal of Seed Science
: Erythrina velutina Willd. is a xerophytic plant native to the Caatinga, whose seeds show heteromorphism in seed coat color, varying between reddish and orangish.
Hannah Lanier de Oliveira, Clarisse Pereira Benedito, Giovanna Dias de Sousa, Pablo Ferreira da Silva, Salvador Barros Torres, Daise Feitoza da Rocha   +5 more
doaj   +1 more source