Results 71 to 80 of about 1,381,766 (368)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Surface Charge Effects for the Hydrogen Evolution Reaction on Pt(111) Using a Modified Grand-Canonical Potential Kinetics Method

Molecules
Surface charges of catalysts have important influences on the thermodynamics and kinetics of electrochemical reactions. Herein, we develop a modified version of the grand-canonical potential kinetics (GCP-K) method based on density functional theory (DFT)
Shaoyu Kong, Min Ouyang, Yi An, Wei Cao, Xiaobo Chen   +4 more
doaj   +1 more source

Beyond traditional coatings, a review on thermal sprayed functional and smart coatings [PDF]

, 2018
Thermal spraying has been present for over a century, being greatly refined and optimised during this time, becoming nowadays a reliable and cost-efficient method to deposit thick coatings with a wide variety of feedstock materials and substrates.
arxiv   +1 more source

SiPMs coated with TPB: coating protocol and characterization for NEXT [PDF]

Journal of Instrumentation, 2012
Submitted to the Journal of Instrumentation on december 26th ...
Álvarez Puerta, Vicente, Agramunt, J., Ball, M., Batallé, M., Bayarri, J., Borges, Filipa I.G.M., Bolink, H., Brine, H., Cárcel García, Sara, Carmona, J.M., Castel, J., Catalá, J.M., Cebrián, Susana, Cervera Villanueva, Anselmo, Chan, D., Conde, Carlos A.N., Dafni, Theopisti, Dias, T.H.V.T, Díaz Medina, José, Esteve, Raúl, Evtoukhovitch, P., Ferrando, J., Fernandes, L.M.P., Ferrario, Paola, Ferreira, Antonio Luis, Ferrer-Ribas, E., Freitas, Elisabete D.C., García, S.A., Gil Ortiz, Alejandro, Giomataris, I., Goldschmidt, Azriel, Gómez, E., Gómez, H., Gómez Cadenas, Juan José, González, K., Gutiérrez, Rafael María, Hauptman, John M., Hernando Morata, J.A., Herrera, D.C., Herrero, Vicente, Iguaz, F.J., Irastorza, Igor Garcia, Kalinnikov, V., Labarga, Luis A., Liubarsky, Igor, Lopes, J.A.M., Lorca Galindo, David, Losada, Marta, Luzón, Gloria, Marí, A., Martín-Albo Simón, Justo, Méndez, A.M., Miller, Tom P., Moiseenko, A., Monrabal Capilla, Francesc, Monteiro, Cristina M.B., Monzó, J.M., Mora, Francisco José, Muñoz Vidal, J., Natal da Luz, H., Navarro, G., Nebot Guinot, Miquel, Nygren, David R., Oliveira, Carlos A.B., Palma, R., Pérez Aparicio, J.L., Pérez, Javier Martin, Radicioni, E., Quinto, M., Renner, Joshua, Ripoll Masferrer, Lluís, Rodríguez, Ángel Y., Rodríguez Samaniego, Javier, Santos, Filomena P., dos Santos, Joaquim M.F., Seguí, Laura, Serra Díaz-Cano, Luis, Shuman, Derek B., Sofka, C., Sorel, Michel, Soriano, A., Spieler, H., Toledo, J.F., Torrent Collell, Jordi, Tomás, A., Tsamalaidze, Zviadi, Vázquez, D., Velicheva, E., Veloso, João F.C.A., Villar, José Ángel, Webb, R.C., Weber, T., White, James T., Yahlali Haddou, Nadia   +93 more
openaire   +7 more sources

Corrosion resistant thermal barrier coating [PDF]

, 1981
A thermal barrier coating system for protecting metal surfaces at high temperature in normally corrosive environments is described. The thermal barrier coating system includes a metal alloy bond coating, the alloy containing nickel, cobalt, iron, or a ...
Hodge, P. E., Levine, S. R., Miller, R. A.   +2 more
core   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

Kinetic regulation of coated vesicle secretion [PDF]

, 2008
The secretion of vesicles for intracellular transport often rely on the aggregation of specialized membrane-bound proteins into a coat able to curve cell membranes. The nucleation and growth of a protein coat is a kinetic process that competes with the energy-consuming turnover of coat components between the membrane and the cytosol.
arxiv   +1 more source

An ammonia sensor based on Lossy Mode Resonances on a tapered optical fibre coated with porphyrin-incorporated titanium dioxide [PDF]

, 2017
The development of a highly sensitive ammonia sensor is described. The sensor is formed by deposition of a nanoscale coating of titanium dioxide, containing a porphyrin as a functional material, onto a tapered optical fibre.
James, Stephen W., Korposh, Sergiy, Lee, Seung-Woo, Mullaney, Kevin, Tatam, Ralph P., Tiwari, Divya   +5 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Optimizing the Structure and Optical Properties of Lanthanum Aluminate Perovskite through Nb⁵⁺ Doping

Nanomaterials
This work involves the introduction of niobium oxide into lanthanum aluminate (LaAlO3) via a conventional solid-state reaction technique to yield LaAlO3:Nb (LaNbxAl1−xO3+δ) samples with Nb5+ doping levels ranging from 0.00 to 0.25 mol%.
Wei Liu, Yang Zou, Yuang Chen, Zijian Lei, Lili Zhao, Lixin Song   +5 more
doaj   +1 more source