Results 31 to 40 of about 112,031 (265)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Corrosion resistant coating fabrication through synergies between SiOC conversion and iron oxidation at high temperatures

npj Materials Degradation
High-temperature organic coatings protect assets well at moderately elevated temperatures. However, they degrade severely at higher temperatures (e.g., above 450 °C), leaving little or no corrosion protection to the substrate.
Ravi Arukula, Taehyun Kim, Joshua Dockter, Xiaoning Qi   +3 more
doaj   +1 more source

AS7341 Spectral Sensor with Machine Learning for Non-Contact Temperature Monitoring in Electrolytic-Plasma Hardening

Sensors
Electrolytic-plasma hardening of steel components requires reliable non-contact temperature monitoring, but traditional pyrometry is complicated by the variable emissivity of steel and the intense radiation of the plasma envelope.
Rinat Kussainov, Aikyn Erboluly, Zhanel Bakyt, Nurlat Kadyrbolat, Rinat Kurmangaliyev, Bauyrzhan Rakhadilov, Vladislav Koc, Aknur Rakhmetollayeva, Zarina Satbayeva   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Entropy-Driven 1D Magnetic Carbon Fibers Embedded into 3D Aerogel Enable Broadband Electromagnetic Wave Absorption

Nano-Micro Letters
Highlights Entropy-driven design is utilized to enhance the electromagnetic loss synergy mechanism. The combination of 1D fibers and 3D aerogel leverages their complementary advantages.
Tingting Zhao, Shiping Shao, Ke Bi, Yunxiang Tang, Lili Wu, Jiurong Liu, Zhou Wang, Fenglong Wang   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Entropy-modulated atomic ripple texturing in two-dimensional transition metal carbonitrides

Nature Communications
Periodically atomic displacement in two-dimensional (2D) ripple texturing offers a promising route for selective modulation of local potential, crucial for advanced electronic engineering.
Minmin Liu, Liting Yang, Zhengchen Wu, Guanyu Chen, Xiangyu Wang, Xiaofen Yang, Guisheng Liang, Renchao Che   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Effect of Electrolytic-Plasma Hardening Time on the Microstructure, Hardness, and Corrosion Behavior of Medium-Carbon Steel

Crystals
This study investigates the effect of electrolytic-plasma hardening time on the microstructure formation, hardness distribution, and corrosion behavior of grade 45 structural steel.
Yeldos Mukhametov, Aibek Shynarbek, Bauyrzhan Rakhadilov, Ainur Zhassulan, Nadir Ibragimov, Kuanysh Ormanbekov, Nurlat Kadyrbolat   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source