Results 41 to 50 of about 263,498 (239)

Target erosion process during broad ion beam sputtering using 3D modeling of ion trajectories

AIP Advances, 2022
Understanding the distribution of particles sputtered from a target requires an appreciation of how ions impinge on the target. In pursuit of this goal, a fully three-dimensional model of the ion trajectories in a broad ion beam, assuming full space ...
Wjatscheslaw Sakiew, Eileen Klocke, Detlev Ristau   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Mesoporous Carbon Sphere‐Enhanced Flexible Pressure Sensor with Superior Linearity and Wide Range for Wearable Health Monitoring

Advanced Electronic Materials
Flexible pressure sensors are pivotal in advancing wearable technologies, particularly in human health monitoring. However, the development of high‐performance pressure sensors is challenged by the intrinsic trade‐offs among precision, sensitivity, and ...
Tianyu Zhu, Wanqing Xu, Chenlin Peng, Lan Shi, Limin Wu   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hardness and scratch response of PVD multilayer coatings [PDF]

, 2009
In the present investigation, novel Cr/CrN, CrN/CrAlN and Cr/CrN/CrAlN multilayered coatings thin films have been developed by dual RF magnetron sputtering.
LAMBERTIN, Michel, NOUVEAU, Corinne, BENLATRECHE, Yacine, MUSTAPHA, Nasri, TLILI, Brahim   +4 more
core  

Corrosion resistant coating fabrication through synergies between SiOC conversion and iron oxidation at high temperatures

npj Materials Degradation
High-temperature organic coatings protect assets well at moderately elevated temperatures. However, they degrade severely at higher temperatures (e.g., above 450 °C), leaving little or no corrosion protection to the substrate.
Ravi Arukula, Taehyun Kim, Joshua Dockter, Xiaoning Qi   +3 more
doaj   +1 more source

AS7341 Spectral Sensor with Machine Learning for Non-Contact Temperature Monitoring in Electrolytic-Plasma Hardening

Sensors
Electrolytic-plasma hardening of steel components requires reliable non-contact temperature monitoring, but traditional pyrometry is complicated by the variable emissivity of steel and the intense radiation of the plasma envelope.
Rinat Kussainov, Aikyn Erboluly, Zhanel Bakyt, Nurlat Kadyrbolat, Rinat Kurmangaliyev, Bauyrzhan Rakhadilov, Vladislav Koc, Aknur Rakhmetollayeva, Zarina Satbayeva   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Entropy-Driven 1D Magnetic Carbon Fibers Embedded into 3D Aerogel Enable Broadband Electromagnetic Wave Absorption

Nano-Micro Letters
Highlights Entropy-driven design is utilized to enhance the electromagnetic loss synergy mechanism. The combination of 1D fibers and 3D aerogel leverages their complementary advantages.
Tingting Zhao, Shiping Shao, Ke Bi, Yunxiang Tang, Lili Wu, Jiurong Liu, Zhou Wang, Fenglong Wang   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source