Results 41 to 50 of about 112,031 (265)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Investigation of target erosion profiles sputter-eroded by a low-energy broad ion beam

AIP Advances, 2021
The demand for ion beam sputtering (IBS) coated substrates is growing. In order to find new fields of application for IBS coating technology, it is necessary to understand in detail the distributions of the involved particles in an industrial-scale ...
Wjatscheslaw Sakiew, Eileen Klocke, Detlev Ristau   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Approximation of the Profile of Gas Turbine Engine Blades

Advanced Engineering Research
Introduction. Increasing the durability of gas turbine engine (GTE) blades is achieved through the use of special protective coatings on their surface.
M. E. Soloviev, Y. N. Shuleva, S. L. Baldaev, L. Kh. Baldaev   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

UV coatings using Ta2O5-SiO2 quantized nanolaminates [PDF]

EPJ Web of Conferences
In the last few years, quantized nanolaminates (QNL) have become increasingly popular as a metamaterial in the development for optical coatings. Experiments were often performed using IBS or ALD coating techniques, which yield excellent accuracy but are ...
Bärtschi Manuel, Waldner Stephan, Steger Fabian, Frei Thomas, Schwyn Thöny Silvia, Maeder Xavier   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Influence of Mg and Al alloying additions on the corrosion mechanisms of Hot-dipped Zn-Mg-Al coatings: role of microstructure and phase distribution

npj Materials Degradation
Systematic investigations into the individual effects of increasing alloying additions of Mg and Al on the corrosion mechanisms of Zn-Mg-Al coatings have demonstrated that microstructural phases and their surface distribution determine the anodic and ...
A. D. Malla, G. Williams, D. A. Britton, F. E. Goodwin, Ana P. Domingos Cardoso, T. Richards, D. J. Penney, J. H. Sullivan   +7 more
doaj   +1 more source

The Impact of Electrolytic Cell Parameters on the Boiling Rate of the Electrolyte During Electrolytic Plasma Processing

Computation
This study investigates the influence of electrolytic cell parameters on the electrolyte boiling rate during electrolytic plasma processing, a critical stage for plasma formation and subsequent surface modification.
Rinat Kurmangaliyev, Yeldos Mukhametov, Bauyrzhan Rakhadilov, Rinat Kussainov, Nurlat Kadyrbolat   +4 more
doaj   +1 more source