Results 51 to 60 of about 618,953 (309)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Corrosion resistant coating fabrication through synergies between SiOC conversion and iron oxidation at high temperatures

npj Materials Degradation
High-temperature organic coatings protect assets well at moderately elevated temperatures. However, they degrade severely at higher temperatures (e.g., above 450 °C), leaving little or no corrosion protection to the substrate.
Ravi Arukula, Taehyun Kim, Joshua Dockter, Xiaoning Qi   +3 more
doaj   +1 more source

Mathematical modeling of technological parameters of laser powder surfacing based on approximation of the deposition track profile

Российский технологический журнал
Objectives. Laser powder surfacing is a promising mechanical engineering technology used to effectively restore worn surfaces of parts and create special coatings with valuable properties.
Mikhail E. Soloviev, Denis V. Malyshev, Sergey L. Baldaev, Lev Kh. Baldaev   +3 more
doaj   +1 more source

Application of CrAlN coatings on carbide substrates in routing of MDF [PDF]

, 2007
This study deals with the development of Chromium Aluminium Nitride (CrAlN) hard coatings (by varying the nitrogen content in the plasma, the target bias voltage, the working pressure and the deposition time) and their characterization by physical and ...
COLLET, Robert, DJOUADI, Mohamed Abdou, FERREIRA-MARTIN, Jean-Pierre, LABIDI, Chafik, NOUVEAU, Corinne   +4 more
core   +5 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Entropy-modulated atomic ripple texturing in two-dimensional transition metal carbonitrides

Nature Communications
Periodically atomic displacement in two-dimensional (2D) ripple texturing offers a promising route for selective modulation of local potential, crucial for advanced electronic engineering.
Minmin Liu, Liting Yang, Zhengchen Wu, Guanyu Chen, Xiangyu Wang, Xiaofen Yang, Guisheng Liang, Renchao Che   +7 more
doaj   +1 more source

Heat Treated NiP–SiC Composite Coatings: Elaboration and Tribocorrosion Behaviour in NaCl Solution [PDF]

, 2009
Tribocorrosion behaviour of heat-treated NiP and NiP–SiC composite coatings was investigated in a 0.6 M NaCl solution. The tribocorrosion tests were performed in a linear sliding tribometer with an electrochemical cell interface.
A Hovestad, A Miranda, C. B. Santos, C. F. Malfatti, CF Malfatti, CF Malfatti, D Landolt, E Färber, F Assi, F Bigdeli, H. Hololeczek, H. M. Veit, HG Schenzel, I Apachitei, I Garcia, I Garcia, IR Aslanyan, IR Aslanyan, J Fransaer, J Takadoum, J.-P. Bonino, JP Bonino, JP Celis, JW Graydon, KH Hou, L Fedrizzi, M Kaisheva, M Verelst, M. Metzner, N Guglielmi, P Jemmely, P Jemmely, P Ponthiaux, Q Zhao, S Mischler, S Shawki, SL Kuo, YL Shi   +37 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Investigation of target erosion profiles sputter-eroded by a low-energy broad ion beam

AIP Advances, 2021
The demand for ion beam sputtering (IBS) coated substrates is growing. In order to find new fields of application for IBS coating technology, it is necessary to understand in detail the distributions of the involved particles in an industrial-scale ...
Wjatscheslaw Sakiew, Eileen Klocke, Detlev Ristau   +2 more
doaj   +1 more source

Development of nickel phosphorus coatings containing micro particles of talc phyllosilicates [PDF]

, 2013
The present work aims to characterized nickel phosphorus coatings co-deposited with talc particles on steel. The NiP-talc composite deposits were developed to serve as hard coatings with a lubricating effect at 600 C.
Alexis, Joël, Bonino, Jean-Pierre, Etcheverry, Bernard, Gaussens, Clélia   +3 more
core   +3 more sources