Results 61 to 70 of about 618,953 (309)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Effect of Electrolytic-Plasma Hardening Time on the Microstructure, Hardness, and Corrosion Behavior of Medium-Carbon Steel

Crystals
This study investigates the effect of electrolytic-plasma hardening time on the microstructure formation, hardness distribution, and corrosion behavior of grade 45 structural steel.
Yeldos Mukhametov, Aibek Shynarbek, Bauyrzhan Rakhadilov, Ainur Zhassulan, Nadir Ibragimov, Kuanysh Ormanbekov, Nurlat Kadyrbolat   +6 more
doaj   +1 more source

UV coatings using Ta2O5-SiO2 quantized nanolaminates [PDF]

EPJ Web of Conferences
In the last few years, quantized nanolaminates (QNL) have become increasingly popular as a metamaterial in the development for optical coatings. Experiments were often performed using IBS or ALD coating techniques, which yield excellent accuracy but are ...
Bärtschi Manuel, Waldner Stephan, Steger Fabian, Frei Thomas, Schwyn Thöny Silvia, Maeder Xavier   +5 more
doaj   +1 more source

Synthesis and characterisation of nanocrystalline ZrN PVD coatings on AISI 430 stainless steel [PDF]

, 2019
The nanocrystalline films of zirconium nitride have been synthesized using ion-plasma vacuum-arc deposition technique in combination with high-frequency discharge (RF) on AISI 430 stainless steel at 150oC.
Baturin, A. A., Garkusha, I. E., Muratov, R. M., Romaniuk, S. P., Skoblo, T. S., Starikov, V. V., Taran, A. V., Taran, V. S.   +7 more
core   +1 more source

Novel types of anti-ecloud surfaces

, 2013
In high power RF devices for space, secondary electron emission appears as the main parameter governing the multipactor effect and as well as the e-cloud in large accelerators.
Aguilera, L., Caspers, F., Dávila, M. E., Galán, L., González, L. A., Montero, I., Nistor, V., Pinto, P. Costa, Raboso, D., Taborelli, M., Ulrich, U., Wolk, D.   +11 more
core   +1 more source

Polyaniline coated micro-capillaries for continuous flow analysis of aqueous solutions [PDF]

, 2013
The inner walls of fused silica micro-capillaries were successfully coated with polyaniline nanofibres using the “grafting” approach. The optical response of polyaniline coatings was evaluated during the subsequent redoping–dedoping processes with ...
Asijati, Barta, Bartonek, Berna, Berrada, Blighe, Borecki, Castrellon-Uribe, Chen, Chiang, Crowley, de Oliveira, Dermot Diamond, Epstein, Fay, Fernando Benito-Lopez, Florea, Florea, Furukawa, Genies, He, Ho, Huang, Huang, Huang, Hugotlegoff, Kebiche, Kuswandi, Lapresta-Fernandez, Larisa Florea, Laska, Lechuga, Lindfors, Liu, Manigandan, Mazeikiene, McCurley, Mehta, Morais, O’Hare, Perez-Palacios, Pulido-Tofino, Sequeira, Stamenov, Taurozzi, Valcarcel, Virji, Wallace, Weigl   +48 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Drug Distribution and Stent Retention of Drug Eluting Stents [PDF]

, 2008
In this paper the examinations of drug eluting coronary stents are shown, such as the morphology of the coatings before expansion, drug distribution, the methodology and the value of stent retention.
Balázs, T., Bognár, Eszter, Dobránszky, János, Ring, Gy.   +3 more
core  

Effect of reinforcing submicron SiC particles on the wear of electrolytic NiP coatings Part 2: Bi-directional sliding [PDF]

, 2006
As-plated and heat-treated electrodeposited NiP and composite NiP-SiC coatings were investigated in bi-directional ball-on-disc sliding tests. All tests were performed under gross slip conditions.
Aslanyan, I. R., Bonino, Jean-Pierre, Celis, J.-P.   +2 more
core   +2 more sources

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons [PDF]

Cardiovascular Engineering and Technology, 2018
Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain ...
Emily A. Turner, Marzieh K. Atigh, Megan M. Erwin, Uwe Christians, Saami K. Yazdani   +4 more
openaire   +2 more sources