Results 71 to 80 of about 618,953 (309)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The effects of carboxylic acids in aluminum anodizing [PDF]

, 2017
Hard-anodized alumina coatings were formed in sulfuric acid at low temperature and high current density in the presence of carboxylic acid additives. Citric acid, trimesic acid, mellitic acid and ethylenediaminetetraacetic acid (EDTA) were utilized in ...
Koczera, Abby E
core   +1 more source

Microstructural characterization of AISI 431 martensitic stainless steel laser-deposited coatings [PDF]

, 2011
High cooling rates during laser cladding of stainless steels may alter the microstructure and phase constitution of the claddings and consequently change their functional properties.
A Zambon, C Blawert, G Kurdjumow, G Nolze, G Wassermann, I. Hemmati, J. Th. M. De Hosson, JW Elmer, L Ryde, PA Dearnley, R Colaço, S Bontha, S Fukumoto, S Kou, SA David, SI Wright, TF Kelly, V. Ocelík, W Kurz, W Kurz, W Kurz, YP Kathuria, Z Nishiyama   +22 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Approximation of the Profile of Gas Turbine Engine Blades

Advanced Engineering Research
Introduction. Increasing the durability of gas turbine engine (GTE) blades is achieved through the use of special protective coatings on their surface.
M. E. Soloviev, Y. N. Shuleva, S. L. Baldaev, L. Kh. Baldaev   +3 more
doaj   +1 more source

Titanium Nitride and Nitrogen Ion Implanted Coated Dental Materials [PDF]

, 2012
Titanium nitride and/or nitrogen ion implanted coated dental materials have been investigated since the mid-1980s and considered in various applications in dentistry such as implants, abutments, orthodontic wires, endodontic files, periodontal/oral ...
Al Jabbari, Youssef S., Barnes, Ashley C., Berzins, David W., Fehrman, Jennifer, Zapf, Angela M., Zinelis, Spiros   +5 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Influence of Mg and Al alloying additions on the corrosion mechanisms of Hot-dipped Zn-Mg-Al coatings: role of microstructure and phase distribution

npj Materials Degradation
Systematic investigations into the individual effects of increasing alloying additions of Mg and Al on the corrosion mechanisms of Zn-Mg-Al coatings have demonstrated that microstructural phases and their surface distribution determine the anodic and ...
A. D. Malla, G. Williams, D. A. Britton, F. E. Goodwin, Ana P. Domingos Cardoso, T. Richards, D. J. Penney, J. H. Sullivan   +7 more
doaj   +1 more source

The structure and properties of pre-alloyed NiAl-Cr(Co,Hf) spherical powders produced by plasma rotating electrode processing for additive manufacturing

Journal of Materials Research and Technology, 2018
The structure and properties of pre-alloyed Ni41Al41Cr12Co6 spherical powders (the 40–160 μm fraction) produced using the plasma rotating electrode processing technology were studied.
Yu.Yu. Kaplanskii, A.A. Zaitsev, Zh.A. Sentyurina, E.A. Levashov, Yu.S. Pogozhev, P.A. Loginov, I.A. Logachev   +6 more
doaj   +1 more source

Thermal noise in interferometric gravitational wave detectors due to dielectric optical coatings

, 2001
We report on thermal noise from the internal friction of dielectric coatings made from alternating layers of Ta2O5 and SiO2 deposited on fused silica substrates.
, , Abramovici A, Andri M Gretarsson, Blevins R D, Braginsky V B, Cadez A, Crooks D, D R M Crooks, Fraser D B, Fraser D B, Fritschel P, Gianpietro Cagnoli, Gregory M Harry, Gretarsson A M, Gwo D H, Jim Hough, Jones R M, Libbrecht K, Lunin B S, Lück H, Martin M Fejer, Nakagawa N, Nakagawa N, Norio Nakagawa, Peter R Saulson, Rowan S, Scott E Kittelberger, Sheila Rowan, Steven D Penn, Tsubono K, Whitcomb S, Willems P, William J Startin   +33 more
core   +1 more source