Results 161 to 170 of about 14,134 (199)

Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003
Background: The causes of cobalamin (vitamin B12) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency.
Asselt, D.Z.B. van, Thomas, C.M.G., Segers, M.F.G., Blom, H.J., Wevers, R.A., Hoefnagels, W.H.L.   +5 more
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Cobalamin-folate interrelations

Blood Reviews, 1989
Cobalamin deficiency leads to impaired folate function as demonstrated by markedly impaired single-carbon unit transfer into purine, thymidine and methionine. This occurs in the total absence of 'methylH4folate trapping'. In cobalamin deficiency there is impaired synthesis of formylH4folate and raised levels of endogenous formate in blood and liver ...
Rosemary Deacon, M. Lumb, I. Chanarin, Janet Perry   +3 more
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Cobalamin status in children

Journal of Inherited Metabolic Disease, 2010
AbstractCobalamin and the metabolic markers methylmalonic acid and total homocysteine undergo marked changes during childhood. In breastfed infants a metabolic profile indicative of cobalamin deficiency is common. Symptoms of cobalamin deficiency in children differ with age, presenting a continuum from subtle developmental delay to life‐threatening ...
Anne-Lise Bjørke-Monsen, Per Magne Ueland, Per Magne Ueland   +2 more
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Disorders of cobalamin metabolism

Critical Reviews in Oncology/Hematology, 1985
Recent developments in our knowledge of the biochemistry and metabolism of cobalamin have given us some insight into clinical disorders. N2O, which easily induces cobalamin deficiency, both in vivo and in vitro, has greatly contributed to the investigation of the cobalamin deficient state, especially in relation to folate and amino acid metabolism ...
Shinobu Sakamoto, Yasusada Miura, Fumimaro Takaku, Victor Herbert, Yasuhiko Kano   +4 more
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Nitrous Oxide and the Cobalamins

Clinical Science, 1980
Vitamin B12 is able to cleave the anaesthetic gas nitrous oxide and in the process is itself oxidized to an inactive form. This has provided an opportunity for exploring the effect of vitamin B12 deficiency in the experimental animal as well as in man, and hence for unravelling some of the tangled skeins of vitamin B12-folate interrelations.
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Cobalamins and the spectrochemical series

Dalton Transactions, 2008
UV-visible-NIR spectra of a variety of cobalamins were run in water and methanol. A broad absorption band (band A) with extinction coefficients of about an order of magnitude less than those of the alphabeta bands was found in the red and NIR regions for Cl-cobalamin (Cl-cbl), Br-cbl, I-cbl, SC(NH(2))(2)-cbl(+) and SeCN-cbl.
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Subclinical cobalamin deficiency

Current Opinion in Gastroenterology, 2012
This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons.Diagnosis of SCCD depends exclusively on biochemical tests whose individual limitations suggest that combinations of tests are needed, especially in epidemiologic ...
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The Metabolism of the Cobalamins

1970
Publisher Summary This chapter discusses the metabolism of the cobalamins. The chapter discusses the absorption, distribution, and excretion of vitamin B 12 and its coenzymes in ill or apparently healthy animals and humans. Vitamin B 12 is biosynthesized exclusively by microorganisms mainly as a coenzyme. The vitamin is widely distributed in meats,
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Cobalamin in charge

Nature Chemical Biology, 2022
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Cobalamin-Dependent Methyltransferases

Accounts of Chemical Research, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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