Results 51 to 60 of about 43,643 (334)

Global Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis. [PDF]

open access: yes, 2019
The risk of adverse effects of nitrous oxide (N2O) exposure is insufficiently recognized despite its widespread use. These effects are mainly reported through case reports. We conducted an individual patient data meta-analysis to assess the prevalence of
Filhine-Tresarrieu, Pierre   +10 more
core   +3 more sources

Enhanced cobalamin biosynthesis in Ensifer adhaerens by regulation of key genes with gradient promoters

open access: yesSynthetic and Systems Biotechnology, 2022
Cobalamin is an essential human vitamin widely used in the pharmaceutical, food, and feed additive industries and currently produced by bacteria or archaea. Ensifer adhaerens HY-1 is an industrial strain that also produces cobalamin.
Sha Xu   +5 more
doaj  

Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo

open access: yesNature Communications, 2023
Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionine for ...
Johnny Mendoza   +3 more
doaj   +1 more source

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12) [PDF]

open access: yes, 2013
It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes.
Biedendieck, Rebekka   +7 more
core   +1 more source

How I treat anemia in pregnancy: iron, cobalamin, and folate.

open access: yesBlood, 2017
Anemia of pregnancy, an important risk factor for fetal and maternal morbidity, is considered a global health problem, affecting almost 50% of pregnant women. In this article, diagnosis and management of iron, cobalamin, and folate deficiencies, the most
M. Achebe, A. Gafter-Gvili
semanticscholar   +1 more source

Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats. [PDF]

open access: yesJournal of Clinical Investigation, 1991
To determine which parts of the cobalamin (cbl) molecule are required for enzyme activity and which parts, if altered, might inhibit cbl-dependent enzyme activity, we synthesized 16 cbl analogues and administered them to nutritionally normal rats. The cbl analogues, with either modifications of the propionamide side chains of the A-, B-, and C-rings ...
Sally P. Stabler   +3 more
openaire   +3 more sources

Fat digestibility is reduced in old cats with subnormal cobalamin concentrations

open access: yesJournal of Nutritional Science, 2014
Fat digestibility is decreased in old cats for unknown reasons. Subclinical gastrointestinal diseases and pancreatic dysfunction, both related to ageing, can affect food digestibility.
Anna Salas   +9 more
doaj   +1 more source

Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli.

open access: yesBiochemistry, 2018
The methylation of unactivated carbon and phosphorus centers is a burgeoning area of biological chemistry, especially given that such reactions constitute key steps in the biosynthesis of numerous enzyme cofactors, antibiotics, and other natural products
N. Lanz   +6 more
semanticscholar   +1 more source

Nutrient cross-feeding in the microbial world. [PDF]

open access: yes, 2014
The stability and function of a microbial community depends on nutritional interactions among community members such as the cross-feeding of essential small molecules synthesized by a subset of the population.
Seth, Erica C, Taga, Michiko E
core   +2 more sources

Cobalamin (Vitamin B12) Induced a Shift in Microbial Composition and Metabolic Activity in an in vitro Colon Simulation

open access: yesFrontiers in Microbiology, 2018
Cobalamin deficiency is believed to be related to disturbances in cell division, neuropathy, nervous system disease and pernicious anemia. Elderly people are usually advised to supplement their diets with cobalamin.
Yuanyuan Xu   +7 more
semanticscholar   +1 more source

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