Results 41 to 50 of about 876 (161)
An Investigation into the Relationship Between Adenine Modification and Cobamide Lower Base Synthesis [PDF]
, 2023 Cobalamin, also known as vitamin B12 is a widely used cofactor in cellular metabolism but is only synthesized in a few species of prokaryotes. Interestingly, cobalamin in the large intestine is not bioavailable.
Mhlongo, Khethile
core +1 more source
The coenzyme B12 precursor 5,6-dimethylbenzimidazole is a flavin antagonist in Salmonella
Microbial Cell, 2023 Salmonella enterica subsp. enterica sv. Typhimurium str. LT2 (hereafter S. Typhimurium) synthesizes adenosylcobalamin (AdoCbl, CoB12) de novo only under anoxic conditions, but it can assemble the lower ligand loop (a.k.a.
Lahiru Malalasekara +1 more
doaj +1 more source
Cobalamin-dependent and cobamide-dependent methyltransferases [PDF]
Current Opinion in Structural Biology, 2008 Methyltransferases that employ cobalamin cofactors, or their analogs the cobamides, as intermediates in catalysis of methyl transfer play vital roles in energy generation in anaerobic unicellular organisms. In a broader range of organisms they are involved in the conversion of homocysteine to methionine.
Rowena G, Matthews +2 more
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Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics [PDF]
, 2019 The vitamin B12 family of cofactors known as cobamides are essential for a variety of microbial metabolisms. We used comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use across bacteria ...
Mok, Kenny C +13 more
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Structural and functional relations in cobamide-containing reductive dehalogenases from anaerobic bacteria [PDF]
, 2018 Biological degradation of persistent natural and synthetic halogenated hydrocarbons (organohalides) in anoxic environments is a vital part of the global halogen cycle.
Kunze, Cindy
core +1 more source
Scientific Reports, 2022 Cobamides (Cbas) are coenzymes used by cells across all domains of life, but de novo synthesis is only found in some bacteria and archaea. Five enzymes assemble the nucleotide loop in the alpha phase of the corrin ring. Condensation of the activated ring
Victoria L. Jeter +3 more
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Reduction of Cobamides by Reduced Ferredoxin
Journal of Biological Chemistry, 1966 Reduced ferredoxin is capable of reducing nonenzymatically cyano-B12. Spectral studies have shown that B12r (a 1-electron reduced derivative of the vitamin) accumulates in the reaction although the formation of methyl-B12 was observed upon the addition of methyl iodide to the incubation.
H, Weissbach, N, Brot, W, Lovenberg
openaire +2 more sources
mBio, 2022 Acinetobacter baumannii is an opportunistic pathogen typically associated with hospital-acquired infections. Our understanding of the metabolism and physiology of A. baumannii is limited. Here, we report that A.
Elizabeth A. Villa +1 more
doaj +1 more source
Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity [PDF]
, 2013 SummaryCobamides are members of the vitamin B12 family of cofactors that function in a variety of metabolic processes and are synthesized only by prokaryotes. Cobamides produced by different organisms vary in the structure of the lower axial ligand. Here
Taga, Michiko E. +3 more
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Resonance Raman analysis of intracellular vitamin B12 analogs in methanogenic archaea
Analytical Science Advances, 2022 Methanogenic archaea (methanogens) are microorganisms that can synthesize methane. They are found in diverse environments ranging from paddy fields to animal digestive tracts to deep‐sea hydrothermal vents.
Nanako Kanno +4 more
doaj +1 more source