Nutrient smuggling: Commensal gut bacteria‐derived extracellular vesicles scavenge vitamin B12 and related cobamides for microbe and host acquisition [PDF]
Journal of Extracellular Biology, 2022 The processes by which bacteria proactively scavenge essential nutrients in crowded environments such as the gastrointestinal tract are not fully understood.
Martin Warren, Rokas Juodeikis
exaly +3 more sources
Microbes display broad diversity in cobamide preferences [PDF]
mSystemsCobamides, the vitamin B12 (cobalamin) family of cofactors, are used by most organisms but produced by only a fraction of prokaryotes, and are thus considered key shared nutrients among microbes.
Kenny C. Mok +4 more
doaj +5 more sources
Understanding the sources, function, and irreplaceable role of cobamides in organohalide-respiring bacteria [PDF]
Frontiers in MicrobiologyHalogenated organic compounds are persistent pollutants that pose a serious threat to human health and the safety of ecosystems. Cobamides are essential cofactors for reductive dehalogenases (RDase) in organohalide-respiring bacteria (OHRB), which ...
Yaqing Liu
exaly +4 more sources
Cobamide Sharing Is Predicted in the Human Skin Microbiome [PDF]
mSystems, 2022 The skin microbiome is a key player in human health, with diverse functions ranging from defense against pathogens to education of the immune system.
Mary Hannah Swaney +2 more
doaj +4 more sources
Sharing vitamins: Cobamides unveil microbial interactions [PDF]
Science, 2020 Nutritional interdependencies Bacteria and archaea show a wide range of nutritional specialism. Not every organism can synthesize essential components and may need to trade for them. Taking as an example a diverse and interesting family of enzyme cofactors—the cobalt-containing cobamides, which include vitamin B 12
Amanda Shelton +2 more
exaly +7 more sources
Current Biology, 2020 Vitamin B12 is the only known essential human micronutrient made exclusively by prokaryotes. Kennedy and Taga introduce us to the world of cobamides-those cobalt-containing compounds, like B12, that appear to be the proprietary domain of our microbial partners.
Michiko Taga, Kristopher Kennedy
exaly +5 more sources
Resonance Raman analysis of intracellular vitamin B12 analogs in methanogenic archaea [PDF]
Analytical Science Advances, 2022 Methanogenic archaea (methanogens) are microorganisms that can synthesize methane. They are found in diverse environments ranging from paddy fields to animal digestive tracts to deep‐sea hydrothermal vents.
Nanako Kanno +4 more
doaj +2 more sources
Cobamide metabolism, regulation, and adaptation in Mycobacterium tuberculosis [PDF]
Journal of BacteriologyCobamides play a paradoxical but critical role in the biology of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Although Mtb retains nearly all cobalamin (Cbl) biosynthetic genes and encodes multiple cobamide-requiring enzymes ...
Terry Kipkorir +4 more
doaj +2 more sources
A Salvaging Strategy Enables Stable Metabolite Provisioning among Free-Living Bacteria [PDF]
mSystems, 2022 All organisms rely on complex metabolites such as amino acids, nucleotides, and cofactors for essential metabolic processes. Some microbes synthesize these fundamental ingredients of life de novo, while others rely on uptake to fulfill their metabolic ...
Sebastian Gude +2 more
doaj +2 more sources
Laboratory evolution of E. coli with a natural vitamin B12 analog reveals roles for cobamide uptake and adenosylation in methionine synthase-dependent growth [PDF]
Journal of BacteriologyBacteria encounter chemically similar nutrients in their environment, which impact their growth in distinct ways. Among such nutrients are cobamides, the structurally diverse family of cofactors related to vitamin B12 (cobalamin), which function as ...
Kenny C. Mok +3 more
doaj +2 more sources