Results 61 to 70 of about 901 (171)

Darunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir

, 2017
Cobicistat and ritonavir have different inhibitory profiles for drug transporters that could impact the distribution of co-administered drugs. We compared darunavir concentrations in CSF when boosted by cobicistat versus ritonavir relative to plasma ...
Bartels, Hanni, Decosterd, Laurent, Battegay, Manuel, Laurent Decosterd, Marzolini, Catia, Hanni Bartels, Catia Marzolini, Manuel Battegay   +7 more
core   +1 more source

IMPATTO DI COBICISTAT SU DURATA ETOLLERABILITA¿ DI REGIMI ANTIRETROVIRALICONTENENTI TENOFOVIR DIPROXIL FUMARATO [PDF]

, 2018
INTRODUZIONE Il dosaggio di tenofovir alafenamide è stato ridotto da 25 a 10 mg al giorno quando somministrato con farmaci con funzioni di potenziatore.
RESNATI, CHIARA
core   +1 more source

HIV‐Associated Pulmonary Arterial Hypertension in Resource‐Limited Settings: A “Forgotten” Diagnosis, a Great Imitator, and a Multi‐Hit Pulmonary Vasculopathy

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT HIV‐associated pulmonary arterial hypertension (HIV‐PAH) remains one of the most consequential cardiopulmonary complications in people living with HIV (PLWH), persisting despite expanded antiretroviral therapy (ART) coverage. Although contemporary hemodynamic criteria define pulmonary hypertension (PH) as mean pulmonary arterial pressure (mPAP)
Emmanuel Eroume A Egom, Mfopa Adamou, Ibrahima Djouldé, Njimona Ibrahim, Mountchissi Célestin, Lum Abenwi Ambe, Medou Mba Fabrice, Moustapha, René Kamgang   +8 more
wiley   +1 more source

Development and Validation of a Simple and Robust Bioanalytical Method for Simultaneous Quantification of Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Human Plasma Using LC–MS/MS and Its Application in a Pharmacokinetic Study

SEPARATION SCIENCE PLUS, Volume 9, Issue 4, April 2026.
ABSTRACT A simple, sensitive, and selective LC–MS/MS method has been developed and validated, in accordance with ICH M10 guidelines, for the simultaneous quantification of Bictegravir (BTV), Emtricitabine (ECB), and Tenofovir alafenamide (TAM) in human plasma.
Boosi Ravi Kumar, Muvvala Venkatanarayana, Shiva Kumar Koppula, Valluru Rajani Kumar   +3 more
wiley   +1 more source

Pharmacokinetic interactions between cobicistat-boosted elvitegravir and darunavir in HIV-infected patients

, 2017
[Objectives] To evaluate if there are significant drug–drug interactions between cobicistat-boosted elvitegravir and 800 mg darunavir once daily taken simultaneously, as has been suggested previously.[Methods] The study population consisted of three ...
Lopez-Cortes, Luis F, Benmarzouk-Hidalgo, Omar J, Fernández-Magdaleno, Tamara, BenMarzouk-Hidalgo, O. J., Llaves, Silvia, Espinosa, Nuria, Viciana, Pompeyo, López-Cortés, Luis F., Gutierrez-Valencia, Alicia, Gutiérrez Valencia, Alicia   +9 more
core   +1 more source

Effectiveness and safety of two‐drug regimens containing an integrase inhibitor and reverse transcriptase inhibitor in a cohort of virologically suppressed people with HIV: Data from the COMBINE‐2 study

HIV Medicine, Volume 27, Issue 4, Page 572-584, April 2026.
Abstract Objectives This study assessed real‐world effectiveness and safety of switching to dual therapy regimens consisting of an integrase inhibitor (INSTI), and reverse transcriptase inhibitor (RTI), among suppressed people living with HIV in Europe.
Cristina Mussini, Cassidy Henegar, Lambert Assoumou, Stephane de Wit, Margaret Johnson, Eugenia Quiros‐Roldan, Chris Kenyon, Colin Deschanvres, David Zucman, Frank Post, Roya Movahedi, Laura Comi, Julie Fox, Geoffrey Liegeon, Charlotte Martin, Jonathan Edwards, Giorgio Tiecco, Marc Delforge, Leigh Ragone, Bryn Jones, Jean van Wyk, Michael Aboud, Carl Fletcher, Anton Pozniak, Vani Vannappagari   +24 more
wiley   +1 more source

Outcomes by sex following treatment initiation with darunavir/cobicistat in a large Spanish cohort of the CODAR study (GeSIDA 9316) [PDF]

, 2019
[Background] Few women have been included in darunavir/cobicistat clinical development studies, and hardly any of them were antiretroviral experienced or treated with anything other than triple-based therapies.[Objectives] Our aim was to increase our ...
Martínez, Esteban, Galindo, María José, Mateo García, M. G., Rojas, J., Sepúlveda, M. A., García-Fraile, Lucio Jesús, García de Lomas, Juan, Alejos, Belén, Fuente Moral, S. de la, Pérez-Elías, María Jesús, Vivancos-Gallego, María Jesús, Troya, Jesús, Tasias Pitarch, M., Lozano, Fernando, Vilanova-Trillo, L., Campo, S. del, Díez Martínez, Marcos, Ribera, Esteban, Raya-Cruz, M.   +18 more
core   +1 more source

HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study

AIDS Research and Therapy, 2017
Background As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and ...
Marianne Harris, Bruce Ganase, Birgit Watson, P. Richard Harrigan, Julio S. G. Montaner, Mark W. Hull   +5 more
doaj   +1 more source

Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

Drugs in R&D, 2023
Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone.
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi   +10 more
doaj   +1 more source

Systematic Literature Review and Meta-Analysis of Renal Function in Human Immunodeficiency Virus (HIV)-Infected Patients Treated with Atazanavir (ATV)-Based Regimens.

PLoS ONE, 2015
Some HIV antiretroviral therapies (ART) have been associated with renal toxicities, which become of increasing concern as HIV-infected patients age and develop comorbidities.
Sandrine Cure, Florence Bianic, Caroline Espinas, Helene Hardy, Lisa Rosenblatt, Timothy Juday   +5 more
doaj   +1 more source