Results 71 to 80 of about 5,352 (210)

HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study

AIDS Research and Therapy, 2017
Background As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and ...
Marianne Harris, Bruce Ganase, Birgit Watson, P. Richard Harrigan, Julio S. G. Montaner, Mark W. Hull   +5 more
doaj   +1 more source

Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

Drugs in R&D, 2023
Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone.
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi   +10 more
doaj   +1 more source

Darunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir

, 2017
Cobicistat and ritonavir have different inhibitory profiles for drug transporters that could impact the distribution of co-administered drugs. We compared darunavir concentrations in CSF when boosted by cobicistat versus ritonavir relative to plasma ...
Bartels, Hanni, Decosterd, Laurent, Battegay, Manuel, Laurent Decosterd, Marzolini, Catia, Hanni Bartels, Catia Marzolini, Manuel Battegay   +7 more
core   +1 more source

IMPATTO DI COBICISTAT SU DURATA ETOLLERABILITA¿ DI REGIMI ANTIRETROVIRALICONTENENTI TENOFOVIR DIPROXIL FUMARATO [PDF]

, 2018
INTRODUZIONE Il dosaggio di tenofovir alafenamide è stato ridotto da 25 a 10 mg al giorno quando somministrato con farmaci con funzioni di potenziatore.
RESNATI, CHIARA
core   +1 more source

SARS-CoV-2 Infection may be Prevented with Cytochrome Inhibitors: Cobicistat and Ritonavir

, 2022
Objective: Highly contagious character of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of specific drugs have led many scientists worldwide to re-evaluate the molecules currently in use for other diseases/viruses.
Gülten, Ezgi, Birengel, Mehmet Serhat, Kılcıgil, Gülgün, Çınar, Güle, Azap, Alpay, Beşikci, Arzu, Çelik, İsmail, Memikoğlu, Kemal Osman, Akdemir Kalkan, İrem   +8 more
core   +1 more source

Systematic Literature Review and Meta-Analysis of Renal Function in Human Immunodeficiency Virus (HIV)-Infected Patients Treated with Atazanavir (ATV)-Based Regimens.

PLoS ONE, 2015
Some HIV antiretroviral therapies (ART) have been associated with renal toxicities, which become of increasing concern as HIV-infected patients age and develop comorbidities.
Sandrine Cure, Florence Bianic, Caroline Espinas, Helene Hardy, Lisa Rosenblatt, Timothy Juday   +5 more
doaj   +1 more source

A multidisciplinary, AI‐supported quality improvement intervention to manage polypharmacy in aging people with HIV

HIV Medicine, Volume 27, Issue 7, Page 1109-1119, July 2026.
Abstract Objectives Aging people with HIV are increasingly affected by multimorbidity and polypharmacy, which heighten the risk of drug–drug interactions (DDIs) and potentially inappropriate medications (PIMs). This study evaluated a multidisciplinary, AI‐supported quality improvement intervention designed to optimize polypharmacy management in older ...
Jovana Milic, Antonia Pugliese, Michela Belli, Gian Luca Lonardi, Caterina Ruffilli, Tommaso Albano, Marco Visicaro, Martina Ricciardetto, Pierluigi De Cosmo, Chiara Mussi, Francesca Gandolfi, Cristina Mussini, Costantino Grana, Giovanni Guaraldi   +13 more
wiley   +1 more source

Iatrogenic Adrenal Insufficiency Secondary to Combination Therapy with Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine and Interlaminar Triamcinolone Injection in an AIDS Patient

Journal of the International Association of Providers of AIDS Care, 2017
We report the first identified case of suspected iatrogenic adrenal insufficiency after an interlaminar injection of triamcinolone acetonide while on concomitant Stribild (elvitegravir 150 mg/cobicistat 150 mg/tenofovir disoproxil fumarate 300 mg ...
Chanie Wassner PharmD, BCCCP, Sutapa Maiti MD, Kurt Kodroff MD, MMM, Henry Cohen MS, PharmD, FCCM, BCPP, BCGP   +3 more
doaj   +1 more source

Exploring the impact of Cabotegravir‐Rilpivirine long‐acting on weight gain, body composition and quality of life in adults living with HIV

HIV Medicine, Volume 27, Issue 5, Page 727-739, May 2026.
Abstract Introduction Long‐acting injectable antiretroviral therapy (ART) with Cabotegravir (CAB) and Rilpivirine (RPV) offers an alternative to daily oral regimens, improving adherence and patient satisfaction. However, its impact on body composition and metabolism remains underexplored.
Andrea De Vito, Andrea Marongiu, Antonella Cano, Mariangela Puci, Agnese Colpani, Susanna Maria Nuvoli, Maria Grazia Catte, Giulia Moi, Maria Antonietta Deledda, Sergio Uzzau, Giovanni Sotgiu, Franca Deriu, Angela Spanu, Giordano Madeddu   +13 more
wiley   +1 more source

Outcomes by sex following treatment initiation with darunavir/cobicistat in a large Spanish cohort of the CODAR study (GeSIDA 9316) [PDF]

, 2019
[Background] Few women have been included in darunavir/cobicistat clinical development studies, and hardly any of them were antiretroviral experienced or treated with anything other than triple-based therapies.[Objectives] Our aim was to increase our ...
Martínez, Esteban, Galindo, María José, Mateo García, M. G., Rojas, J., Sepúlveda, M. A., García-Fraile, Lucio Jesús, García de Lomas, Juan, Alejos, Belén, Fuente Moral, S. de la, Pérez-Elías, María Jesús, Vivancos-Gallego, María Jesús, Troya, Jesús, Tasias Pitarch, M., Lozano, Fernando, Vilanova-Trillo, L., Campo, S. del, Díez Martínez, Marcos, Ribera, Esteban, Raya-Cruz, M.   +18 more
core   +1 more source