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Protective activity of medicinal plants and their isolated compounds against the toxic effects from the venom of Naja (cobra) species

open access: yesJournal of Ethnopharmacology, 2014
Ethnopharmacological relevance: Various medicinal plants have protective properties against the taxicities of the venom of cobra snake (Naja species).
Muhammad Shahzad   +2 more
exaly   +2 more sources
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Inactivation of thromboplastin by cobra venom

Biochimica et Biophysica Acta, 1950
This paper reports some studies on the anticoagulant effect of cobra venom on chicken blood. It was found that the venom has a strong inactivating or destructive action on thromboplastin, and it is concluded that the destruction of thromboplastin is an essential factor in the anticoagulant effect of cobra venom.
I, KRUSE, H, DAM
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Cobra venom keratoconjunctivitis

BMJ Case Reports
We present a case of cobra venom keratoconjunctivitis, an ocular injury caused by a snake’s defensive mechanism of spitting venom into a predator’s eyes. A male in his 50s reported to the outpatient department of a regional hospital in Songea, Tanzania, with 24 hours of eye pain, photophobia and decreased vision after being sprayed in the face by a ...
Rita Sofia Glazer   +3 more
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Cardiovascular Effects of Cobra Venom

JAMA: The Journal of the American Medical Association, 1963
COBRA VENOM produces profound cardiovascular changes, and envenomed animals maintained by artificial respiration die of circulatory collapse. Evidence to date suggests that both heart and peripheral vessels are affected. In experiments reported herein, cardiac and peripheral vascular changes produced by venom of Naja naja were studied.
K, BHANGANADA, J F, PERRY
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Effect of Cobra Venom on Leucocytes

American Journal of Physiology-Legacy Content, 1958
Intermittent injections of sublethal doses of the venom of Naja haje of Egypt caused temporary leucopenia followed by leucocytosis in guinea-pigs and rabbits. There was always a rise in the percentage of neutrophil leucocytes and a corresponding drop in the percentage of lymphocytes.
F, KHALIL, I, ABOU-EL-NAGA, Z M, RIAD
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Immunization against cobra venom

Experientia, 1971
Durch Behandlung mit Glutardialdehyd wirdNaja-naja-Gift weitgehend entgiftet. Einzeldosen bis zu 20 mg pro Kaninchen konnen ohne Nebenwirkungen injiziert werden. Durch Immunisierung von Kaninchen wird eine gute Antikorperbildung gegenNajanaja-Gift — und vor allem auch gegen die niedermolekularen Toxine — erzielt.
V, Brade, W, Vogt
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The toxic proteins of cobra venom

Biochemical Pharmacology, 1968
Abstract Carboxymethyl cellulose chromatography permits separation of five distinct toxic proteins from the venom of the Indian cobra ( Naja naja ). These account for 90 per cent of the toxicity against mice. After gel filtration on Sephadex G-50 columns, three of the toxic fractions are more potent than the crude venom by factors of 6–9. They differ
P R, Larsen, J, Wolff
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Cobra Bite Following Immunization Against Cobra Venom

JAMA: The Journal of the American Medical Association, 1965
THE INDIAN COBRA ( Naja naja ) is considered by most authorities to be one of the most deadly snakes in the world. In India, where the annual mortality from snakebite may reach 25,000 to 30,000, the bite of the cobra is considered one of the prime offenders. Ahuja and Singh 1 and Puranananda 2 have reviewed the symptomatology of cobra bite.
E D, CANAN, H H, FLOWERS
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Fractionation of egyptian cobra venom

Toxicon, 1974
Abstract Five toxic fractions were isolated from Egyptian Naja haje venom by filtration using Sephadex G-75. Applying immunodiffusion techniques, fractions four and five were found to contain γ(cardiotoxic)- and α(neurotoxic)-like antigenic activity, respectively. The maximum phospholipase A activity was recorded in fraction three.
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Cardiovascular and respiratory effects of cobra venom and a venom fraction

Toxicon, 1966
Abstract The cardiovascular and respiratory effect of whole cobra venom and a purified cobra venom fraction were compared in dogs and cats. Both the crude venom and the fraction affected the respiration of dogs markedly and that of cats to a lesser degree. At lethal doses respiratory failure occurred.
M, Cohen, G B, Sumyk
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