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Association study of optineurin gene polymorphisms T34T and M98K with normal tension glaucoma in a Turkish cohort. [PDF]

open access: yesSci Rep
Erdoğdu Yİ   +4 more
europepmc   +1 more source
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Cocaethylene in Meconium Specimens

Journal of Toxicology: Clinical Toxicology, 1994
Cocaethylene, a metabolite of cocaine and ethanol, exhibits cardiac and neurobehavioral effects. In order to determine the prevalence of this compound in meconium specimens, samples which gave a positive result for benzoylecgonine using fluorescence polarization immunoassay were analyzed by gas chromatography/mass spectrometry for cocaine, cocaethylene
Christine Moore, Jerrold B Leikin
exaly   +3 more sources

Immunotoxicity of Cocaethylene

Immunopharmacology and Immunotoxicology, 1995
This report describes the response of normal human T cells to stimulation in vitro in the presence of nano-micromolar concentrations of cocaethylene. Thymidine incorporation by concanavalin A-stimulated peripheral blood mononuclear cells was generally blunted by cocaethylene, albeit to different degrees depending upon the donor tested. The formation of
F, Chiappelli   +5 more
openaire   +2 more sources

Comparison of intravenous cocaethylene and cocaine in humans

Psychopharmacology, 2000
Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetics of i.v. administered cocaethylene in human
Carl L Hart, P Jatlow, Kevin A Sevarino
exaly   +3 more sources

Cocaethylene hepatotoxicity in mice

Biochemical Pharmacology, 1992
Cocaethylene is a novel metabolite of cocaine formed in the presence of ethanol. When administered to ICR male mice in dosages ranging from 10 to 50 mg/kg, i.p., cocaethylene was found to produce dose-dependent hepatic necrosis in the midlobular zone (zone 2). Severity of the lesion was maximal 12-24 hr after administration. A transient but significant
S M, Roberts   +3 more
openaire   +2 more sources

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