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Psychopharmacology, 1999
Cocaethylene is a unique metabolite of cocaine, produced only in the presence of alcohol. This metabolite is pharmacologically, physiologically and behaviorally active. Further, it has been reported to interact pharmacokinetically with both cocaine and alcohol, an interaction that may mediate, in part, the interaction of cocaine and alcohol.
B F, Sobel, A L, Riley
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Cocaethylene is a unique metabolite of cocaine, produced only in the presence of alcohol. This metabolite is pharmacologically, physiologically and behaviorally active. Further, it has been reported to interact pharmacokinetically with both cocaine and alcohol, an interaction that may mediate, in part, the interaction of cocaine and alcohol.
B F, Sobel, A L, Riley
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Forensic Science International, 1992
GC and GC/MS analysis was used to detect cocaine and cocaethylene in hair extracts of mice injected with 20 mg/kg cocaine hydrochloride or an equivalent dose of cocaethylene fumarate twice daily for 3 weeks. Some mice were fed liquid Lieber-DeCarli diets containing ethanol (26% of total calories) and injected twice daily with the same doses of cocaine ...
Ronald R Watson, Cleamond D Eskelson
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GC and GC/MS analysis was used to detect cocaine and cocaethylene in hair extracts of mice injected with 20 mg/kg cocaine hydrochloride or an equivalent dose of cocaethylene fumarate twice daily for 3 weeks. Some mice were fed liquid Lieber-DeCarli diets containing ethanol (26% of total calories) and injected twice daily with the same doses of cocaine ...
Ronald R Watson, Cleamond D Eskelson
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Journal of Addictive Diseases, 1997
Concurrent use of cocaine and alcohol produces another psychoactive substance known as cocaethylene which has pharmacological properties similar to that of cocaine but which has a plasma half-life three to five times that of cocaine. This slow removal from the body makes it an attractive drug for abuse.
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Concurrent use of cocaine and alcohol produces another psychoactive substance known as cocaethylene which has pharmacological properties similar to that of cocaine but which has a plasma half-life three to five times that of cocaine. This slow removal from the body makes it an attractive drug for abuse.
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Therapeutic Drug Monitoring, 1993
Consumption of ethanol during the course of cocaine binges is common, with an estimated prevalence well in excess of 50%. Cocaine abusers indicate that coingestion of ethanol may enhance and/or prolong the euphoria and reduce unpleasant side effects that may follow. Cocaethylene, an active homologue/metabolite that arises through transesterification of
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Consumption of ethanol during the course of cocaine binges is common, with an estimated prevalence well in excess of 50%. Cocaine abusers indicate that coingestion of ethanol may enhance and/or prolong the euphoria and reduce unpleasant side effects that may follow. Cocaethylene, an active homologue/metabolite that arises through transesterification of
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Cocaethylene: effects on brain systems and behavior
Addiction Biology, 1999AbstractCocaethylene is a psychoactive metabolite formed during the combined consumption of cocaine and ethanol. In this brief review, we discuss several well‐characterized effects of this metabolite with an emphasis on the neurobiological and behavioral correlates of polydrug addiction.
J M, Horowitz, G, Torres
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Cocaethylene produces conditioned place preference in rats
Pharmacology Biochemistry and Behavior, 1995The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place preference apparatus as determined on a baseline test day.
Martin D Schechter, M D Schechter
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Cocaethylene and heart disease during murine AIDS
International Immunopharmacology, 2002Cocaethylene is an active cocaine metabolite believed to play a causative role in the increased incidence of sudden cardiac death in individuals who co-administer alcohol and cocaine. Prolonged and excessive abuse of cocaine and alcohol will result in marked alteration of host immunity to increased susceptibility to infection.
Yingying, Liu +7 more
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Acute Cocaine Responses Following Cocaethylene Infusion
The American Journal of Drug and Alcohol Abuse, 2007We report results of a randomized, double-blind, placebo-controlled, within-subject study (n = 8) to determine the ability of cocaethylene to modulate acute responses to cocaine and identify significant pharmacokinetic interactions between cocaine and cocaethylene.
Jennifer, Baker +4 more
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Cocaine and cocaethylene: Effects on extracellular dopamine in the primate
Psychopharmacology, 1995Cocaine and cocaethylene (a psychoactive metabolite of concurrent cocaine and ethanol consumption) were studied in the anesthetized vervet monkey. The ability of each to elevate extracellular DA in the caudate nucleus was assessed using microdialysis probes acutely lowered through chronic guide cannulae.
P I Jatlow, Charles W Bradberry
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Cocaethylene-induced lethality in mice is potentiated by alcohol
Alcohol, 1995Mice of the heterogeneously bred HS line were concurrently administered intraperitoneal injections of either 95, 75, 60, or 48 mg/kg cocaethylene or 48, 38, or 30 mg/kg cocaethylene in conjunction with the non-lethal dose of 6.0 g/kg (20% w/v) alcohol. Results indicate that alcohol administration significantly potentiated cocaethylene-induced lethality.
S M, Meehan, M D, Schechter
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