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Cocaethylene in Meconium Specimens
Journal of Toxicology: Clinical Toxicology, 1994Cocaethylene, a metabolite of cocaine and ethanol, exhibits cardiac and neurobehavioral effects. In order to determine the prevalence of this compound in meconium specimens, samples which gave a positive result for benzoylecgonine using fluorescence polarization immunoassay were analyzed by gas chromatography/mass spectrometry for cocaine, cocaethylene
D E, Lewis, C M, Moore, J B, Leikin
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Comparison of intravenous cocaethylene and cocaine in humans
Psychopharmacology, 2000Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetics of i.v. administered cocaethylene in human
C L, Hart +3 more
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Cocaethylene is more potent than cocaine in mediating lethality
Pharmacology Biochemistry and Behavior, 1991Cocaethylene is a pharmacologically active cocaine metabolite that is formed in the presence of ethanol by the activity of liver enzymes. The pharmacology of cocaethylene has not been extensively investigated and its acute toxicity is unknown. The acute toxicity of cocaethylene was compared to cocaine in Swiss-Webster mice. The LD50 of cocaethylene was
W L, Hearn +4 more
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Cocaethylene produces conditioned place preference in rats
Pharmacology Biochemistry and Behavior, 1995The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place preference apparatus as determined on a baseline test day.
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Cocaethylene formation in rat, dog, and human hepatic microsomes
Life Sciences, 1999The dog and rat are important animal models for studying the role of cocaethylene in the pharmacodynamic interaction between cocaine and ethanol. In a previous study in our laboratory it was found that a cocaine dose of 3 mg/kg IV and ethanol 1 g/kg IV failed to produce detectable concentrations of cocaethylene in the plasma of dogs.
N, Song, R B, Parker, S C, Laizure
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Cocaine and cocaethylene: Effects on extracellular dopamine in the primate
Psychopharmacology, 1995Cocaine and cocaethylene (a psychoactive metabolite of concurrent cocaine and ethanol consumption) were studied in the anesthetized vervet monkey. The ability of each to elevate extracellular DA in the caudate nucleus was assessed using microdialysis probes acutely lowered through chronic guide cannulae.
Charles W Bradberry
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Immunotoxicity of Cocaethylene
Immunopharmacology and Immunotoxicology, 1995This report describes the response of normal human T cells to stimulation in vitro in the presence of nano-micromolar concentrations of cocaethylene. Thymidine incorporation by concanavalin A-stimulated peripheral blood mononuclear cells was generally blunted by cocaethylene, albeit to different degrees depending upon the donor tested. The formation of
F, Chiappelli +5 more
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Cocaethylene hepatotoxicity in mice
Biochemical Pharmacology, 1992Cocaethylene is a novel metabolite of cocaine formed in the presence of ethanol. When administered to ICR male mice in dosages ranging from 10 to 50 mg/kg, i.p., cocaethylene was found to produce dose-dependent hepatic necrosis in the midlobular zone (zone 2). Severity of the lesion was maximal 12-24 hr after administration. A transient but significant
S M, Roberts +3 more
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