Results 1 to 10 of about 51,709 (292)

Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors. [PDF]

Bioorg Med Chem Lett, 2014
Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo.
Pulgar VM, Keith Harp J.
europepmc   +4 more sources

Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors [PDF]

Molecules, 2023
Psychostimulant use disorders (PSUD) affect a growing number of men and women and exert sizable public health and economic burdens on our global society.
Melinda Hersey, Mattingly K. Bartole, Claire S. Jones, Amy Hauck Newman, Gianluigi Tanda   +4 more
doaj   +2 more sources

Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. [PDF]

PLoS ONE, 2014
Dopamine is a catecholamine with multiple physiological functions, playing a key role in nervous system; however its participation in reproductive processes and sperm physiology is controversial.
Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Concha   +5 more
doaj   +9 more sources

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Frontiers in Cellular Neuroscience, 2021
Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and molecular
Sarah Threlfell, Sarah Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Brent J. Ryan, Natalie Connor-Robson, Natalie Connor-Robson, Nicola J. Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Nora Bengoa-Vergniory, Richard Wade-Martins, Richard Wade-Martins, Andrew Ewing, Stephanie J. Cragg, Stephanie J. Cragg, Katherine R. Brimblecombe, Katherine R. Brimblecombe   +19 more
doaj   +1 more source

Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters

Biomedicines, 2023
Monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT, respectively), are important therapeutic targets due to their essential roles in the brain.
Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Song   +6 more
doaj   +1 more source

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source

Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors

Scientific Reports, 2021
The human norepinephrine transporter (NET) is an established drug target for a wide range of psychiatric disorders. Conventional methods that are used to functionally characterize NET inhibitors are based on the use of radiolabeled or fluorescent ...
Hubert J. Sijben, Wieke M. van Oostveen, Peter B. R. Hartog, Laura Stucchi, Andrea Rossignoli, Giovanna Maresca, Lia Scarabottolo, Adriaan P. IJzerman, Laura H. Heitman   +8 more
doaj   +1 more source

Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells

Reproductive Biology and Endocrinology, 2022
Background Three primary monoamines—serotonin, norepinephrine, and dopamine—play major roles in the placenta-fetal brain axis. Analogously to the brain, the placenta has transport mechanisms that actively take up these monoamines into trophoblast cells ...
Veronika Vachalova, Rona Karahoda, Martina Ottaviani, Kasin Yadunandam Anandam, Cilia Abad, Christiane Albrecht, Frantisek Staud   +6 more
doaj   +1 more source

Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2009
Drugs that inhibit dopamine (DA) reuptake through actions at the dopamine transporter (DAT) have been proposed as candidates for development as pharmacotherapies for cocaine abuse. Accordingly, it is important to understand the potential pharmacological interactions of cocaine with other drugs acting at the DAT.
Gianluigi, Tanda, Amy Hauck, Newman, Aaron L, Ebbs, Valeria, Tronci, Jennifer L, Green, Ronald J, Tallarida, Jonathan L, Katz   +6 more
openaire   +2 more sources

What mechanisms are responsible for the reuptake of levodopa-derived dopamine in parkinsonian striatum?

Frontiers in Neuroscience, 2016
Levodopa is the most effective medication for motor symptoms in Parkinson’s disease. However, various motor and non-motor complications are associated with levodopa treatment, resulting from altered levodopa-dopamine metabolism with disease progression ...
Haruo Nishijima, Haruo Nishijima, Masahiko Tomiyama, Masahiko Tomiyama   +3 more
doaj   +1 more source