In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity
Neurobiology of Disease, 2022 The G2019S mutation of LRRK2 represents a risk factor for idiopathic Parkinson's disease. Here, we investigate whether LRRK2 kinase activity regulates susceptibility to the environmental toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP).
Salvatore Novello +15 more
doaj +1 more source
Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
core +2 more sources
Regulated Expression and Function of the Somatodendritic Catecholamine Neurotransmitter Transporters
Journal of Pharmacological Sciences, 2005 Termination of neurotransmission at catecholaminergic synapses is well documented by the transporters for dopamine and norepinephrine, members of the Na+/Cl−-dependent neurotransmitter transporter family, which accumulates released transmitters within ...
Shigeo Kitayama, Chiharu Sogawa
doaj +1 more source
Journal of Translational Medicine, 2023 Background Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG), a norepinephrine analog taken ...
Joana Grand-Guillaume +8 more
doaj +1 more source
Preclinical discovery of duloxetine for the treatment of depression [PDF]
, 2012 Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María +4 more
core +2 more sources
Pathophysiology, prognosis and treatment of tardive dyskinesia
Therapeutic Advances in Psychopharmacology, 2022 Tardive dyskinesia (TD), a movement disorder associated with antipsychotics, most frequently affects the lower face and jaw muscles, but can also affect walking, breathing and use of the hands and limbs.
Hiroyoshi Takeuchi +2 more
doaj +1 more source
Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]
, 2018 Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core +2 more sources
The use of LeuT as a receptor model for antidepressant development
Health Science Journal of Indonesia, 2012 Selective serotonin re-uptake inhibitors (SSRIs) merupakan golongan antidepresan yang cukup selektif terhadap serotonin re-uptake transporter (SERT). Sertraline dan fluoxetine merupakan golongan SSRI yang mempunyai afinitas kuat terhadap SERT serta mampu
Lina Rustanti
doaj +3 more sources
Domperidone Inhibits Clostridium botulinum C2 Toxin and Bordetella pertussis Toxin
Toxins, 2023 Bordetella pertussis toxin (PT) and Clostridium botulinum C2 toxin are ADP-ribosylating toxins causing severe diseases in humans and animals. They share a common translocation mechanism requiring the cellular chaperones Hsp90 and Hsp70, cyclophilins, and
Jinfang Jia +6 more
doaj +1 more source
Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]
, 2008 Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE +5 more
core +1 more source