Results 21 to 30 of about 51,709 (292)

Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism

Neurobiology of Disease, 2011
The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in synaptic plasticity and function.
Faiza Ferdousy, William Bodeen, Kyle Summers, Olugbenga Doherty, O'Neil Wright, Nahed Elsisi, George Hilliard, Janis M. O'Donnell, Lawrence T. Reiter   +8 more
doaj   +1 more source

STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO)

Jurnal Kimia Riset, 2023
Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression.
Dandi Irawan, Bambang Wijianto, Harianto IH   +2 more
doaj   +1 more source

Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection [PDF]

Neuroscience, 2011
Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the striatum. We have previously reported that cocaine inhibits the DAT within 4-5 s of i.v.
J T, Yorgason, S R, Jones, R A, España
openaire   +2 more sources

Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice

Frontiers in Behavioral Neuroscience, 2019
In the laboratory, long-term social recognition memory (SRM) in mice is highly susceptible to proactive and retroactive interference. Here, we investigate the ability of novel designed dopamine (DA) re-uptake inhibitors (rac-CE-123 and S-CE-123) to block
Judith Camats-Perna, Predrag Kalaba, Karl Ebner, Simone B. Sartori, Harish Vuyyuru, Nilima Y. Aher, Vladimir Dragačević, Nicolas Singewald, Mario Engelmann, Mario Engelmann, Gert Lubec   +10 more
doaj   +1 more source

Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

Translational Psychiatry, 2023
Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly different effects on behavior, neurochemistry, and potential for addiction.
Jacqueline D. Keighron, Jordi Bonaventura, Yang Li, Jae-Won Yang, Emily M. DeMarco, Melinda Hersey, Jianjing Cao, Walter Sandtner, Michael Michaelides, Harald H. Sitte, Amy Hauck Newman, Gianluigi Tanda   +11 more
doaj   +1 more source

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms. [PDF]

, 2020
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones.
Biglia, Nicoletta, Birkhaeuser, Martin, Brincat, Mark, Celis-Gonzales, Cuauhtémoc, Depypere, Herman, Egarter, Christian, Fait, Tomas, Genazzani, Andrea, Goldstein, Steven, Mueck, Alfred, Palacios, Santiago, Panay, Nick, Ruan, Xiangyan, Simoncini, Tommaso, Skouby, Sven O   +14 more
core   +4 more sources

Structure-activity relationships of dopamine- and norepinephrine-uptake inhibitors.

Chemical and Pharmaceutical Bulletin, 1990
Quantitative structure-activity relationship (QSAR) analysis of 3-phenyl-1-indanamines, 1-amino-4-aryltetralins, and 6-phenylpyrrolo[2,1-a] isoquinolines has been performed for catecholamine-uptake inhibition activities. Similar equations were obtained for these series of congeners indicating a common tendency that the increase in hydrophobicity of the
T, Tomita, Y, Inami, Y, Terada
openaire   +3 more sources

Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells

Frontiers in Pharmacology, 2013
The serotonin (5-HT) uptake system is supposed to play a crucial part in vascular functions by fine-tuning the local concentration of 5-HT in the vicinity of 5-HT2 receptors in vascular smooth muscle cells.
Rachel Wai-sum Li, Cui eYang, Yiu-Wa eKwan, Shun-Wan eChan, Simon Ming-Yuen Lee, George Pak-Heng Leung   +5 more
doaj   +1 more source

Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes

Frontiers in Pharmacology, 2021
Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market in the last decades.
Nuria Nadal-Gratacós, Nuria Nadal-Gratacós, Ana Sofia Alberto-Silva, Míriam Rodríguez-Soler, Míriam Rodríguez-Soler, Edurne Urquizu, Maria Espinosa-Velasco, Kathrin Jäntsch, Marion Holy, Xavier Batllori, Xavier Berzosa, David Pubill, Jordi Camarasa, Harald H. Sitte, Harald H. Sitte, Elena Escubedo, Raúl López-Arnau   +16 more
doaj   +1 more source