Results 1 to 10 of about 169,266 (282)
Transport of γ-aminobutyrate and
Biochemical Journal, 1991 The uptakes of gamma-aminobutyrate (GABA) and L-glutamate into synaptic vesicles isolated from rat brain were compared with respect to the effects of 4-acetamido-4′-isothiocyanostilbene-2,2′- disulphonic acid (SITS), 4,4′-di-isothiocyanostilbene-2,2′-disulphonic acid (DIDS) and 5-nitro-2-(3-phenylpropylamino)benzoic acid (N144), agents known to block ...
E.M. Fykse, Frode Fonnum
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Pharmacological Profile of the “Triple” Monoamine Neurotransmitter Uptake Inhibitor, DOV 102,677
Cellular and Molecular Neurobiology, 2006 1. The molecular and behavioral pharmacology of DOV 102,677 is characterized. 2. This characterization was performed using radioligand binding and neurotransmitter uptake assays targeting the monoamine neurotransmitter receptors. In addition, the effects of DOV 102,677 on extracellular neurotransmitter levels were investigated using in vivo ...
Piotr Popik +7 more
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Recognition of Psychostimulants, Antidepressants, and Other Inhibitors of Synaptic Neurotransmitter Uptake by the Plasma Membrane Monoamine Transporters [PDF]
The AAPS Journal, 2008 The plasma membrane monoamine transporters terminate neurotransmission by removing dopamine, norepinephrine, or serotonin from the synaptic cleft between neurons. Specific inhibitors for these transporters, including the abused psychostimulants cocaine and amphetamine and the tricyclic and SSRI classes of antidepressants, exert their physiological ...
Christopher K. Surratt +2 more
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eLife, 2016 Neurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential.
Yuji Okamoto +6 more
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ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain
Biomolecules, 2023 D-serine is an important signalling molecule, which activates N-methyl D-aspartate receptors (NMDARs) in conjunction with its fellow co-agonist, the neurotransmitter glutamate.
Karthik Subramanian Krishnan +1 more
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The use of LeuT as a receptor model for antidepressant development
Health Science Journal of Indonesia, 2012 Selective serotonin re-uptake inhibitors (SSRIs) merupakan golongan antidepresan yang cukup selektif terhadap serotonin re-uptake transporter (SERT). Sertraline dan fluoxetine merupakan golongan SSRI yang mempunyai afinitas kuat terhadap SERT serta mampu
Lina Rustanti
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PLoS ONE, 2021 Glutamate plays diverse roles in neuronal cells, affecting cell energetics and reactive oxygen species (ROS) generation. These roles are especially vital for neuronal cells, which deal with high amounts of glutamate as a neurotransmitter.
Vitaly A Selivanov +3 more
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Role of the endogenous cannabinoid system in nicotine addiction: novel insights
Frontiers in Psychiatry, 2015 Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and human clinical studies have shown a pivotal role of the cannabinoid system in nicotine addiction.
Islam Hany Gamaleddin +8 more
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Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
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