Structure and Gating Dynamics of Na+/Cl– Coupled Neurotransmitter Transporters
Frontiers in Molecular Biosciences, 2019 Neurotransmitters released at the neural synapse through vesicle exocytosis are spatiotemporally controlled by the action of neurotransmitter transporters.
Deepthi Joseph +3 more
doaj +1 more source
Cloning, expression, and localization of a rat brain high-affinity glycine transporter [PDF]
, 1992 A cDNA clone encoding a glycine transporter has been isolated from rat brain by a combined PCR and plaque-hybridization strategy. mRNA synthesized from this clone (designated GLYT1) directs the expression of sodium-and chloride-dependent, high-affinity ...
Brecha, Nicholas +4 more
core +1 more source
Regulated Expression and Function of the Somatodendritic Catecholamine Neurotransmitter Transporters
Journal of Pharmacological Sciences, 2005 Termination of neurotransmission at catecholaminergic synapses is well documented by the transporters for dopamine and norepinephrine, members of the Na+/Cl−-dependent neurotransmitter transporter family, which accumulates released transmitters within ...
Shigeo Kitayama, Chiharu Sogawa
doaj +1 more source
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]
, 2017 Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y +12 more
core +1 more source
Discriminating depression, physical and social anhedonia by neurotransmitter related challenge tests [PDF]
, 2016 The aim of this study was to investigate, if anhedonia, a salient component of depression, shows similar response patterns to neurotransmitter challenge tests as depression, and if the two questionnaire based components Physical (PA) and Social (SA ...
Hennig, Juergen, Netter, Petra
core +2 more sources
Basic & Clinical Pharmacology & Toxicology, 2022 Burgeoning literature demonstrates that monoamine transporters with high transport capacity but lower substrate affinity (i.e., uptake 2) contribute meaningfully to regulation of monoamine neurotransmitter signalling.
Brady L. Weber +2 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2019 Vesicular storage of neurotransmitters, which allows their subsequent exocytotic release, is essential for chemical transmission in the central nervous system.
María T. Miras-Portugal +20 more
doaj +1 more source
Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons [PDF]
, 2006 The mechanism by which synaptic vesicles (SVs) are recruited to the release site is poorly understood. One candidate mechanism for trafficking of SVs is the myosin-actin motor system.
Goda, Y, Tokuoka, H
core +1 more source
Can a Selective Serotonin Reuptake Inhibitor Act as a Glutamatergic Modulator?
Current Therapeutic Research, 2017 Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft.
Marcos Emilio Frizzo, PhD
doaj +1 more source
Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]
, 2014 Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash +4 more
core +2 more sources