Results 1 to 10 of about 3,108 (161)

Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. [PDF]

PLoS ONE, 2014
Dopamine is a catecholamine with multiple physiological functions, playing a key role in nervous system; however its participation in reproductive processes and sperm physiology is controversial.
Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Concha   +5 more
doaj   +12 more sources

Factors derived from human exfoliated deciduous teeth stem cells reverse neurological deficits in a zebrafish model of Parkinson's disease [PDF]

Journal of Dental Sciences
Background/purpose: Mesenchymal stem cells exhibit therapeutic efficacy for brain injury. This study examined the effect of mesenchymal stem cells derived from human exfoliated deciduous teeth (SHED) on alleviating symptoms of Parkinson's disease (PD ...
Yong-Ren Chen, Chin-Chean Wong, Yi-No Chen, Bing-Heng Yang, Po-Hui Lee, Chia-Yang Shiau, Kuo-Chuan Wang, Chung-Hsing Li   +7 more
doaj   +2 more sources

Identification of NUDT5 Inhibitors From Approved Drugs

Frontiers in Molecular Biosciences, 2020
Recent studies have revealed the important role of NUDT5 in estrogen signaling and breast cancer, but research on the corresponding targeted therapy has just started.
Xin-Yu Tong, Xuan Liao, Min Gao, Bo-Min Lv, Xiao-Hui Chen, Xin-Yi Chu, Qing-Ye Zhang, Hong-Yu Zhang   +7 more
doaj   +1 more source

Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. [PDF]

PLoS ONE, 2016
Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. To understand the molecular mechanisms of the disease, an in vitro model is important.
Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Freed   +3 more
doaj   +1 more source

Dissociation of the role of the prelimbic cortex in interval timing and resource allocation: beneficial effect of norepinephrine and dopamine reuptake inhibitor nomifensine on anxiety-inducing distraction

Frontiers in Integrative Neuroscience, 2012
Emotional distracters impair cognitive function. Emotional processing is dysregulated in affective disorders such as depression, phobias, schizophrenia, and PTSD.
Alexander R Matthews, Alexander R Matthews, Olivia H. He, Mona eBuhusi, Mona eBuhusi, Catalin V Buhusi, Catalin V Buhusi   +6 more
doaj   +1 more source

Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]

, 1994
Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
core   +1 more source

Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. [PDF]

, 2012
Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder. Patients have episodes that last 1 to 4 hours and are precipitated by alcohol, coffee, and stress.
Edwards, Robert H, Fan, Xueliang, Fu, Ying-Hui, Hess, Ellen J, Karouani, Maha, Lee, Hsien-yang, Nakayama, Junko, Pothos, Emmanuel N, Ptácek, Louis J, Shen, Yiguo, Xu, Ying   +10 more
core   +2 more sources

Monoaminergic Antidepressants in the Relief of Pain: Potential Therapeutic Utility of Triple Reuptake Inhibitors (TRIs)

Pharmaceuticals, 2011
Over 75% of depressed patients suffer from painful symptoms predicting a greater severity and a less favorable outcome of depression. Imaging, anatomical and functional studies have demonstrated the existence of common brain structures, neuronal pathways
Bruno P. Guiard, Alain M. Gardier, Guillaume Hache, François Coudore   +3 more
doaj   +1 more source

Selective enhancement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia [PDF]

, 2010
The superior efficacy of atypical vs. classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their ability to enhance mesocortical dopamine (DA) function.
Artigas, Francesc, Bortolozzi, Analía, Masana, Mercè   +2 more
core   +1 more source

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain

BMC Neuroscience, 2008
Background Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain
Undieh Ashiwel S, Vongtau Habiba OU, Tyeryar Kimberly R   +2 more
doaj   +1 more source