Cell Transplantation, 1997 Intracranial implantation of polymer-encapsulated PC-12 cells has been shown to improve motor behavioral performance in animal models of Parkinson's disease. The purpose of this blinded study was to examine whether such improvement is associated with the
Thyagarajan Subramanian M.D. +12 more
doaj +1 more source
Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking [PDF]
, 2014 Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine.
A Agrawal +55 more
core +1 more source
6R-L-erythro-5,6,7,8-Tetrahydrobiopterin and Dopamine Release
Pteridines, 1995 We previously reported that intracerebroventricular administration of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BJL), a cofactor for aromatic amino acid hydroxylases and nitric oxide synthase, induces an increase in DOPA levels (as an index of DA ...
Miwa Soichi, Koshimura Kunio
doaj +1 more source
Drug metabolism by flavin-containing monooxygenases of human and mouse [PDF]
, 2016 Introduction: Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. / Areas covered: We focus on the role of FMOs in the metabolism of drugs in human and mouse.
Phillips, IR, Shephard, EA
core +1 more source
Neurotoxicity induced by mephedrone: an up-to-date review [PDF]
, 2017 BACKGROUND: Mephedrone is a β-ketoamphetamine belonging to the family of synthetic cathinones, an emerging class of designer drugs known for their hallucinogenic and psychostimulant properties as well as for their abuse potential.
Busardo', FRANCESCO PAOLO +6 more
core +1 more source
Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]
, 2008 Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE +5 more
core +1 more source
Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission.: Accumbic DA system in STOP KO mice [PDF]
, 2008 International audienceThe microtubule-associated stable tubule only polypeptide (STOP) protein plays a key-role in neuron architecture and synaptic plasticity.
Bouvrais-Veret C. +11 more
core +3 more sources
Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances – The case of the benzofuran 5-MAPB [PDF]
, 2016 Novel psychoactive substances (NPS) are increasingly prevalent world-wide although their pharmacological characteristics are largely unknown; those with stimulant properties, due to interactions with the dopamine transporter (DAT), have addictive ...
Beuming +49 more
core +2 more sources
Multi‐Channel Neural Interface for Neural Recording and Neuromodulation
Small Methods, Volume 10, Issue 3, 9 February 2026.This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim +9 more
wiley +1 more source
Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor. [PDF]
, 2019 Neuromodulation plays a critical role in brain function in both health and disease, and new tools that capture neuromodulation with high spatial and temporal resolution are needed.
Beyene, Abraham G +11 more
core +1 more source