Results 31 to 40 of about 3,127 (178)

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

ヘキサナール刺激でドーパミンを放出した PC12 細胞のドーパミンの再蓄積作用 [PDF]

, 2017
　すべての食品に匂い（香り）がある．食品に含まれる匂い（香り）物質は，食品中の栄養素と同様に体内に取り込まれ，生理作用を示すと考えている． ヘキサナールは炭素数6 の直鎖アルデヒドであり，植物特有の新鮮な香りを構成している物質の1 つである． これまでに，私たちは，ヘキサナールがラット脳線条体切片及びラット副腎褐色細胞腫（PC12）細胞からのドーパミン放出を促進することを報告している． 　ドーパミンを放出した細胞は，次の刺激に応答するために，細胞内にドーパミンを再蓄積する必要がある． 本研究では ...
Kobayashi, Yoko, 小林, 葉子
core  

Advances in studying phasic dopamine signaling in brain reward mechanisms [PDF]

, 2013
The last sixty years of research has provided extraordinary advances of our knowledge of the reward system. Since its discovery as a neurotransmitter by Carlsson and colleagues (1), dopamine (DA) has emerged as an important mediator of reward processing.
Addy, Nii A., Neugebauer, Nichole M., Rathbun, Liza, Solecki, Wojciech, Wickham, Robert J., Wightman, R. Mark   +5 more
core   +1 more source

Association between the use of levodopa/carbidopa, Alzheimer's disease biomarkers, and cognitive decline among participants in the National Alzheimer's Coordinating Center Uniform Data Set

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION This retrospective study investigates whether exposure to levodopa/carbidopa (LA/CA) medication is associated with modified Alzheimer's disease (AD) trajectories. METHODS Multivariate analysis used cerebrospinal fluid (CSF) biomarker information included in the National Alzheimer's Coordinating Center Uniform Data Set for subjects
Zsuzsa Sárkány, Joana Damásio, Sandra Macedo‐Ribeiro, Pedro M. Martins   +3 more
wiley   +1 more source

Therapeutic Targets and Molecular Mechanisms of Calycosin in the Treatment of Depression: Insights From Chronic Mild Stress Animal Models

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
Calycosin modulates TrkB–MEK1/2–Erk1/2–CREB pathway for mitigating depression. ABSTRACT Background Depression is a complex psychiatric disorder with limited therapeutic options and various side effects. Calycosin, a bioactive compound derived from Astragalus membranaceus, possesses multiple pharmacological properties.
Guowei Gong, Yaqun Liu, Zhenxia Zhang, Yuzhong Zheng   +3 more
wiley   +1 more source

Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines [PDF]

, 2018
Novel psychoactive substances (NPS) may have unsuspected addiction potential through possessing stimulant properties. Stimulants normally act at the dopamine transporter (DAT) and thus increase dopamine (DA) availability in the brain, including nucleus ...
Davidson, Colin, Dutta, Neelakshi, Opacka-Juffry, Jolanta, Sahai, Michelle A   +3 more
core   +3 more sources

Action Potential Firing Patterns Regulate Dopamine Release via Voltage‐Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo

Advanced Science, Volume 12, Issue 7, February 17, 2025.
Sun et al. uncover a novel dopamine transmission pathway: the membrane potential or action potential firings not only trigger dopamine release, but also modulate dopamine release by directly targeting voltage‐sensitive D2 receptor via the voltage‐sensing site D131, mediating the facilitation of voltage‐gated calcium channels, thus tuning dopamine ...
Xiaoxuan Sun, Lili Yin, Zhongjun Qiao, Muhammad Younus, Guoqing Chen, Xi Wu, Jie Li, Xinjiang Kang, Huadong Xu, Li Zhou, Yinglin Li, Min Gao, Xingyu Du, Yuqi Hang, Zhaohan Lin, Liyuan Sun, Qinglong Wang, Ruiying Jiao, Lun Wang, Meiqin Hu, Yuan Wang, Rong Huang, Yiman Li, Qihui Wu, Shujiang Shang, Shu Guo, Qian Lei, Haifeng Shu, Lianghong Zheng, Shirong Wang, Feipeng Zhu, Panli Zuo, Bing Liu, Changhe Wang, Quanfeng Zhang, Zhuan Zhou   +35 more
wiley   +1 more source

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]

, 2010
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M., Grady, Sharon R., Lester, Henry A., Marks, Michael J., McIntosh, J. Michael, McKinney, Sheri, Miwa, Julie M., Patzlaff, Natalie E., Steele, Andrew D.   +8 more
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What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit. [PDF]

, 2014
The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this ...
Bannerman, D.M., Barkus, C., Harrison, P.J., Rawlins, J.N.P., Sanderson, D.J., Walton, M.E.   +5 more
core   +1 more source