Results 41 to 50 of about 3,127 (178)
Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 6, Page 720-742, December 2024.Abstract Most central nervous system (CNS) active drugs are organic cations, which need carrier proteins for efficient transfer through the blood–brain barrier (BBB). A genetically still unidentified proton organic cation (H+/OC) antiporter is found in several tissues, including endothelial cells of the BBB.
Cauzar Ali Khan +3 more
wiley +1 more source
Nomifensine in parkinsonism. [PDF]
British Journal of Clinical Pharmacology, 1977 1. The effect of nomifensine was compared with that of placebo in a double‐blind crossover study in patients with parkinsonism. 2. Of the 29 patients who entered the study, three were previously untreated and 26 continued their L‐DOPA or other antiparkinsonian therapy, or both, during the trial. 3.
D M, Park, L J, Findley, P F, Teychenne
openaire +2 more sources
DEPRESSION ASSESSMENT in BRAZIL - the 1ST APPLICATION of the MONTGOMERY-ASBERG DEPRESSION RATING-SCALE [PDF]
, 1987 ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,RUA BOTUCATU,862 1 ANDAR,BR-04023 São Paulo,SP,BRAZILHOSP SERVIDOR PUBL ESTADUAL FRANCISCO MORATO OLIVEIRA,DEPT PSYCHIAT & MED PSYCHOL,São Paulo,BRAZILESCOLA PAULISTA MED,DEPT PSYCHOBIOL,RUA BOTUCATU,862 1 ANDAR,BR ...
Calil, H. M. +5 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han +5 more
wiley +1 more source
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice [PDF]
, 2002 Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field.
Alcântara, F.b. +4 more
core +2 more sources
European Journal of Neuroscience, Volume 59, Issue 7, Page 1460-1479, April 2024.Dopaminergic neurons from the dorsal raphe nucleus or the ventral tegmental area project to the medial and lateral orbitofrontal cortex. Optical stimulation of dopamine release in slices can detect dopamine concentration of ~50 nM in medial or lateral orbitofrontal cortex slices using fast‐scan cyclic voltammetry. Dopamine concentration can be enhanced
Duncan J. Noble +3 more
wiley +1 more source
A multi-site, double-blind, placebo-controlled pilot clinical trial to evaluate the efficacy of buspirone as a relapse-prevention treatment for cocaine dependence [PDF]
, 2014 Objective—To evaluate the potential efficacy of buspirone as a relapse-prevention treatment for cocaine dependence. Method—A randomized, double-blind, placebo-controlled, 16-week pilot trial conducted at six clinical sites between August 2012 and June ...
Chartier, Karen G. +6 more
core +1 more source
Smart Slides for Optical Monitoring of Cellular Processes
Advanced Functional Materials, Volume 34, Issue 6, February 5, 2024.Single wall carbon nanotubes (SWCNTs) exhibit fluorescence in the near‐infrared (NIR, >880 nm) and can be effectively functionalized with DNA to serve as highly sensitive sensors. These versatile SWCNT sensors can be coated on diverse surfaces, forming smart functional sensor coatings.
Julia Ackermann +6 more
wiley +1 more source
Food Science &Nutrition, Volume 12, Issue 1, Page 450-458, January 2024.In this study, we aimed to examine the anti‐PD components of C. officinalis flowers and investigate their molecular mechanisms. Five active compounds from the extracts were identified via LC‐QTOF‐MS/MS. 3,4‐Dicaffeoylquinic acid, isorhamnetin 3‐O‐glucoside and calenduloside E were shown to bind to the pocket region of the Hsp90α protein and then ...
Xuanming Zhang +6 more
wiley +1 more source
Stem Cells International, Volume 2024, Issue 1, 2024.Background. Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis‐related processes. However, the prognostic significance of m6A‐related lncRNAs and their associations with stemness in low‐grade glioma (LGG) remain to be clarified. Methods.
Dahua Xu +13 more
wiley +1 more source