Results 11 to 20 of about 3,127 (178)
The Dopamine Transporter Is a New Target for Ischemic Stroke. [PDF]
CNS Neurosci TherDopamine transporter (DAT) inhibition or high level of DA treatment could be explored as a new strategy for ischemic stroke. DA and its D1R might be an important mechanism for the restoration of the balance of synaptic function and neurons protection against ischemic stroke.
Cheng YQ +5 more
europepmc +2 more sources
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's. [PDF]
Eur J NeurosciAbstract Ca2+ entry into nigrostriatal dopamine (DA) neurons and axons via L‐type voltage‐gated Ca2+ channels (LTCCs) contributes, respectively, to pacemaker activity and DA release and has long been thought to contribute to vulnerability to degeneration in Parkinson's disease. LTCC function is greater in DA axons and neurons from substantia nigra pars
Brimblecombe KR +10 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Transition Metal‐free Selenium‐mediated Aryl Amines via Reduction of Nitroarenes
ChemSusChem, Volume 16, Issue 15, August 7, 2023., 2023 An efficient selenium‐mediated methodology for the reduction of nitroarenes to anilines with NaBH4 in water was developed. Na2Se was demonstrated to be the effective reducing agent involved in the reaction mechanism. This finding led us to unveil an unconventional mild protocol for the selective reduction of nitroarenes bearing useful yet labile ...
Antonella Capperucci +3 more
wiley +1 more source
Alzheimer's &Dementia, Volume 19, Issue 4, Page 1343-1357, April 2023., 2023 Regulatory mechanism of lysosome biogenesis induced by LH2‐051 treatment. LH2‐051, one of the lysosome‐enhancing compounds (LYECs), promotes lysosome biogenesis via a DAT‐CDK9‐TFEB signaling axis. LH2‐051–induced inhibition of DAT enhances the degradation of amyloid beta (Aβ) plaques and improves the learning, memory, and cognitive function of APP/PS1 ...
Limin Yin +11 more
wiley +1 more source
Brain and Behavior, Volume 13, Issue 2, February 2023., 2023 Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) mutation is a common genetic risk factor of Parkinson's disease (PD). Presynaptic dysfunction is an early pathogenic event associated with dopamine (DA) dysregulation in striatum of the brain. DA uptake activity of DA uptake transporter (DAT) affects synaptic plasticity and motor and non‐motor ...
Philip Wing‐Lok Ho +10 more
wiley +1 more source
ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022 Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen +3 more
wiley +1 more source
Biosensing with Fluorescent Carbon Nanotubes
Angewandte Chemie, Volume 134, Issue 18, April 25, 2022., 2022 Optical biosensors are important tools for basic research and non‐invasive diagnostics. Carbon nanotubes are versatile near‐infrared fluorescent and non‐bleaching materials that can be chemically functionalized to detect a broad variety of biomolecules.
Julia Ackermann +3 more
wiley +1 more source
Influence of mirtazapine on salivary cortisol in depressed patients [PDF]
, 2003 Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C. +3 more
core +1 more source
Characteristics of the Runway Model of Intracranial Self-stimulation Behavior and Comparison with Other Motivated Behaviors [PDF]
, 2014 Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated
Esumi, Satoru +4 more
core +1 more source