Results 161 to 170 of about 67,744 (195)

An Accidental Death Related to Cocaine, Cocaethylene, and Caffeine

Journal of Forensic Sciences, 1993
Abstract Cocaethylene is often found in body fluids after concurrent use of alcohol and cocaine. Current research is showing that cocaethylene is more toxic than cocaine. The case presented here involves a death that is due to cocaine, cocaethylene, and caffeine. The cocaethylene concentrations found were 0.16 mg/L (blood)
L J, Caughlin, R L, O'Halloran
openaire   +2 more sources

Gas chromatographic detection of cocaine and cocaethylene in hair of mice chronically injected with cocaine or cocaethylene and fed ethanol

Forensic Science International, 1992
GC and GC/MS analysis was used to detect cocaine and cocaethylene in hair extracts of mice injected with 20 mg/kg cocaine hydrochloride or an equivalent dose of cocaethylene fumarate twice daily for 3 weeks. Some mice were fed liquid Lieber-DeCarli diets containing ethanol (26% of total calories) and injected twice daily with the same doses of cocaine ...
S V, Pirozhkov, R R, Watson, C D, Eskelson   +2 more
openaire   +2 more sources

Cocaine and Cocaethylene Binding in Human Serum

American Journal of Clinical Pathology, 1995
The binding of cocaine (COC) and cocaethylene (CE) in human serum was studied by equilibrium dialysis. Scatchard analysis suggested a high-affinity binder (Ka, 2.56 x 10(4)L/mol; Bo, 7.38 x 10(-5) mol/L) and a low-affinity binder (Ka, 4.47 x 10(3)L/mol; Bo, 2.77 x 10(-4) mol/L) for COC.
openaire   +2 more sources

Direct cardiotoxic effects of cocaine and cocaethylene on isolated cardiomyocytes

International Journal of Cardiology, 1996
We investigated the cardiotoxic effects of cocaine and cocaethylene on the Ca2+ flux responsible for excitation-contraction coupling in isolated ventricular rat myocytes. We simultaneously measured intracellular Ca2+ transients and cell length in isolated cardiac myocytes loaded with a fluorescent Ca2+ indicator, indo-1, during electrical field ...
H, Bai, K, Otsu, M N, Islam, H, Kuroki, M, Terada, M, Tada, C, Wakasugi   +6 more
openaire   +2 more sources

Subjective and cardiovascular effects of cocaethylene in humans

Psychopharmacology, 1993
Preclinical studies have shown cocaethylene (the ethyl ester of benzoylecgonine) to produce pharmacologic effects of similar magnitude to those of cocaine. These observations, however, cannot establish whether or not cocaethylene produces cocaine-like subjective effects.
openaire   +2 more sources

Cocaethylene-induced kindling of seizure effects: Cross-specificity with cocaine

Pharmacology Biochemistry and Behavior, 1996
Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days. On the fifth day, mice were injected with either the same drug that was administered on days 1-4 or the
S M, Meehan, M D, Schechter
openaire   +2 more sources

Cocaine and cocaethylene binding to human placenta in vitro

American Journal of Obstetrics and Gynecology, 1997
The aim of the study was to determine the binding profiles of cocaine and its ethyl homolog, cocaethylene, in human placenta.Pooled whole human placental homogenates supplemented with either nonlabeled cocaine or cocaethylene over the concentration range 10 to 5000 x 10(-7) mol/L were submitted for equilibrium dialysis.
openaire   +2 more sources

Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves

Brain Research, 2004
Cocaethylene is a naturally occurring cocaine derivative that has been used as a tool in both clinical studies of cocaine reward and as a potential model compound for agonist substitution therapy in cocaine dependence. It is equipotent to cocaine at inhibiting dopamine uptake in-vitro and in-vivo.
Hajime A, Tokuno, Charles W, Bradberry, Brian, Everill, Samuel K, Agulian, Steven, Wilkes, Ronald M, Baldwin, Gilles D, Tamagnan, Jeffery D, Kocsis   +7 more
openaire   +2 more sources

Thin-layer Chromatographic Detection of Cocaethylene in Human Urine

American Journal of Clinical Pathology, 1994
A thin-layer chromatographic method was developed for the detection of cocaethylene and cocaine in human urine. Following a standard solid-phase extraction of urine buffered to pH 9.3, the concentrated extract was chromatographed in a solvent consisting of hexane:toluene:diethylamine (65:20:5 mL).
openaire   +2 more sources

Cocaine and Cocaethylene Binding to Human Tissues: A Preliminary Study

Therapeutic Drug Monitoring, 1996
The tissue binding of cocaine (COC) and cocaethylene (CE) was investigated by equilibrium dialysis of homogenates of whole human tissue supplemented with either COC or CE at concentrations of 10 and 50 microM for each drug. Concentrations of COC and CE were measured by high-pressure liquid chromatography.
openaire   +2 more sources