Results 161 to 170 of about 67,569 (184)
Some of the next articles are maybe not open access.
Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases
Drug Metabolism and Disposition, 2003Carboxylesterases are important in the metabolism of cocaine, catalyzing the hydrolysis of cocaine to its two major metabolites, benzoylecgonine and ecgonine methyl ester. In the presence of ethanol, some cocaine undergoes transesterification with ethanol instead of hydrolysis with water producing the active metabolite, cocaethylene. The metabolic fate
S Casey, Laizure +3 more
openaire +2 more sources
Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves
Brain Research, 2004Cocaethylene is a naturally occurring cocaine derivative that has been used as a tool in both clinical studies of cocaine reward and as a potential model compound for agonist substitution therapy in cocaine dependence. It is equipotent to cocaine at inhibiting dopamine uptake in-vitro and in-vivo.
Hajime A, Tokuno +7 more
openaire +2 more sources
Synapse, 1998
The use of Drosophila as a model to study the behavioral consequences of stimulant drugs was analyzed in an active preparation of decapitated Drosophila. Application of cocaine and cocaethylene to discrete nerve cord cells regulating motor programs of behavior produced striking patterns of behavioral activity in a concentration-related manner.
G, Torres, J M, Horowitz
openaire +2 more sources
The use of Drosophila as a model to study the behavioral consequences of stimulant drugs was analyzed in an active preparation of decapitated Drosophila. Application of cocaine and cocaethylene to discrete nerve cord cells regulating motor programs of behavior produced striking patterns of behavioral activity in a concentration-related manner.
G, Torres, J M, Horowitz
openaire +2 more sources
Cocaine and Cocaethylene Binding to Human Tissues: A Preliminary Study
Therapeutic Drug Monitoring, 1996The tissue binding of cocaine (COC) and cocaethylene (CE) was investigated by equilibrium dialysis of homogenates of whole human tissue supplemented with either COC or CE at concentrations of 10 and 50 microM for each drug. Concentrations of COC and CE were measured by high-pressure liquid chromatography.
openaire +2 more sources
An Overview of Cocaethylene, An Alcohol-Derived, Psychoactive, Cocaine Metabolite
Journal of Psychoactive Drugs, 1992Cocaethylene is a psychoactive ethyl homologue of cocaine, and is formed exclusively during the coadministration of cocaine and alcohol. Not a natural alkaloid of the coca leaf, cocaethylene can be identified in the urine, blood, hair, and neurological and liver tissue samples of individuals who have consumed both cocaine and alcohol.
openaire +2 more sources
Studies of Cocaethylene (Ethylcocaine) Formation by Human Tissues in Vitro
Journal of Analytical Toxicology, 1994The potential for different human tissues to form cocaethylene (ethylcocaine) (EC) was evaluated by incubation of homogenates of brain, kidney, liver, lung, and placenta in vitro with cocaine (COC) and ethanol. Only liver yielded measurable concentrations of EC over time, accompanied by a decrease in COC concentration.
openaire +2 more sources
Prevalence of Cocaethylene in the Hair of Pregnant Women
Journal of Analytical Toxicology, 1993G J, DiGregorio +3 more
openaire +2 more sources
Cocaethylene: Toxicological and Methodological Considerations
Therapeutic Drug Monitoring, 1996S. B. Gock, J. M. Jentzen
openaire +1 more source