Results 151 to 160 of about 67,569 (184)
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Cocaine and Cocaethylene Binding in Human Serum
American Journal of Clinical Pathology, 1995The binding of cocaine (COC) and cocaethylene (CE) in human serum was studied by equilibrium dialysis. Scatchard analysis suggested a high-affinity binder (Ka, 2.56 x 10(4)L/mol; Bo, 7.38 x 10(-5) mol/L) and a low-affinity binder (Ka, 4.47 x 10(3)L/mol; Bo, 2.77 x 10(-4) mol/L) for COC.
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Subjective and cardiovascular effects of cocaethylene in humans
Psychopharmacology, 1993Preclinical studies have shown cocaethylene (the ethyl ester of benzoylecgonine) to produce pharmacologic effects of similar magnitude to those of cocaine. These observations, however, cannot establish whether or not cocaethylene produces cocaine-like subjective effects.
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Cocaine and Cocaethylene Binding to Human Milk
American Journal of Clinical Pathology, 1998The binding of cocaine and its ethyl analog, cocaethylene, to human milk was studied using equilibrium dialysis at 4 degrees C. For cocaine, a low-affinity, high-capacity binder was noted (equilibrium constant of association, Ka, 3.12 x 10(3) L/mol; concentration of binding sites, B0, 3.85 x 10(-4) mol/L), as well as a very low affinity, high-capacity ...
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An Accidental Death Related to Cocaine, Cocaethylene, and Caffeine
Journal of Forensic Sciences, 1993Abstract Cocaethylene is often found in body fluids after concurrent use of alcohol and cocaine. Current research is showing that cocaethylene is more toxic than cocaine. The case presented here involves a death that is due to cocaine, cocaethylene, and caffeine. The cocaethylene concentrations found were 0.16 mg/L (blood)
L J, Caughlin, R L, O'Halloran
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Cocaethylene formation in rat, dog, and human hepatic microsomes
Life Sciences, 1999The dog and rat are important animal models for studying the role of cocaethylene in the pharmacodynamic interaction between cocaine and ethanol. In a previous study in our laboratory it was found that a cocaine dose of 3 mg/kg IV and ethanol 1 g/kg IV failed to produce detectable concentrations of cocaethylene in the plasma of dogs.
Ning Song, Robert B Parker
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Cocaine and cocaethylene binding to human placenta in vitro
American Journal of Obstetrics and Gynecology, 1997The aim of the study was to determine the binding profiles of cocaine and its ethyl homolog, cocaethylene, in human placenta.Pooled whole human placental homogenates supplemented with either nonlabeled cocaine or cocaethylene over the concentration range 10 to 5000 x 10(-7) mol/L were submitted for equilibrium dialysis.
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Detection of Cocaine, Norcocaine, and Cocaethylene in the Meconium of Premature Neonates
Journal of Forensic Sciences, 1994Abstract Our objective was to investigate the methodologic detection of cocaine abuse during pregnancy by determining the viability of meconium analysis for cocaine and its metabolites using chromatographic procedures as an alternative to urine testing using enzyme multiplied immunoassay technique.
S, Browne +5 more
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Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse
General Pharmacology: The Vascular System, 19951. The premorbid behaviors produced by the administration of cocaine, ethanol, their combination, as well as a metabolite produced by their co-administration, viz. cocaethylene, were defined, determined and quantified in the HS strain of mice. 2. The LD50 for ethanol was 9.71 g/kg in males and 9.45 g/kg in females, whereas the LD50 values in male and ...
S M, Meehan, M D, Schechter
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Effects of ethanol on cocaine metabolism: Formation of cocaethylene and norcocaethylene
Toxicology and Applied Pharmacology, 1992The coabuse of cocaine and ethanol occurs with high frequency and increases the risk of cocaine-related morbidity and mortality. The mechanisms mediating the toxic interactions of cocaine and ethanol are not clearly defined. This study examined the effects of acute ethanol administration on the metabolism of cocaine in the male Wistar rat ...
R A, Dean +4 more
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Cocaethylene: A current understanding of the active metabolite of cocaine and ethanol
American Journal of Emergency Medicine, 1994Cocaine and ethanol abuse remains a major problem in our society. The active metabolite of the co-ingestion of cocaine and ethanol, cocaethylene, has been reported recently. This active and potentially toxic metabolite has enormous implications for emergency physicians. This article is a brief review of the current understanding of cocaethylene and its
John S Rose
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