Results 211 to 220 of about 11,001,215 (252)

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

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Cocaine‐related movement disorders

Movement Disorders, 1993
AbstractWe describe four patients, two with Tourette's syndrome, one with the combination of idiopathic dystonia and essential‐like tremor, and one with tardive dystonia, who noted marked exacerbation of their movement disorders after exposure to cocaine.
F E, Cardoso, J, Jankovic
openaire   +3 more sources

Homeopathy on the integrative care of cocaine-related disorders (Cocacrack-3 Study)

Neurological Sciences and Neurosurgery, 2023
Background: An effective pharmacotherapy for cocaine use disorder is still needed. Previous results showed a clinically significant difference between the effects of fifty-millesimal homeopathic potencies of Opium and Erythroxylum coca compared to ...
U. Adler, K. Denez, Lívia Crespo Drago, Heloisa São, Thiago Alexsander da Costa Pereira, M. Ligia, Reis Bellaguarda, Lia Lira, Olivier Sanders, E. de Moura Campos, Matheus Halex Ferreira de Matos, D. Simões, Tainá Rocha Josino, H. de, F. Santos, A. de Toledo Cesar, Noemia Liege, Maria da Cunha Bernardo, Rinaldo Ferreira, Erlandson Uchôa, Lacerda, Elaine Cristina Coelho Baptista, Javier Salvador Gamarra, M. Adler, Edson Zangiacomi Martinez   +24 more
openaire   +2 more sources

Preliminary examination of the orexin system on relapse-related factors in cocaine use disorder.

Brain Research, 2020
RATIONALE Current evidence and literature reviews provide a strong justification for examining the orexin receptor (OXR) system as a therapeutic target in substance use disorders, including cocaine and other psychostimulants.
R. Suchting, J. Yoon, Guadalupe G. San Miguel, C. Green, M. Weaver, Jessica Vincent, G. Fries, Joy M. Schmitz, S. Lane   +8 more
semanticscholar   +1 more source

Role of Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment of Addiction and Related Disorders: A Systematic Review.

Current Drug Abuse Reviews, 2018
BACKGROUND Addiction and related disorders are devastating with their tremendous social, psychological, and physical consequences for which development of optimally effective treatments is long overdue. Repetitive Transcranial Magnetic Stimulation (rTMS)
Ramkrishna Makani, B. Pradhan, Umang C. Shah, Tapan Parikh   +3 more
semanticscholar   +1 more source

Psychiatric Comorbidity and Addiction Severity Differences in Patients With ADHD Seeking Treatment for Cannabis or Cocaine Use Disorders

Journal of Attention Disorders, 2019
Objective: The objective of this study was to compare psychiatric comorbidity and consumption-related variables in ADHD patients seeking treatment for cocaine, cannabis, or both.
N. Martínez-Luna, C. Daigre, F. Palma-Álvarez, M. Perea-Ortueta, L. Grau-López, C. Roncero, Eudald Castell-Panisello, J. Ramos-Quiroga   +7 more
semanticscholar   +1 more source

Effects of attentional bias modification therapy on the cue reactivity and cognitive control networks in participants with cocaine use disorders

The American Journal of Drug and Alcohol Abuse, 2019
Background While attentional bias modification therapy (ABMT) alters drug-related behaviors in some substance users, results have been mixed in individuals with cocaine use disorders (CUD).
A. Mayer, A. Dodd, C. Wilcox, S. Klimaj, E. Claus, A. Bryan   +5 more
semanticscholar   +1 more source

Effects of chronic cocaine exposure on the circadian rhythmic expression of the clock genes in reward‐related brain areas in rats

Behavioural Brain Research, 2019
&NA; Drug addiction is a widespread social problem, which not only brings adverse consequences to the human body, but also causes great burden to the society.
De-Quan Wang, Xin-Ling Wang, Chong Wang, Yuan Wang, Su-Xia Li, Kefei Liu   +5 more
semanticscholar   +1 more source

Comparative hazards of acute myocardial infarction among hospitalized patients with methamphetamine- or cocaine-use disorders: A retrospective cohort study.

Drug and Alcohol Dependence, 2017
BACKGROUND It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking.
Russell C. Callaghan, M. Halliday, J. Gatley, J. Sykes, Lawren Taylor, Claire Benny, S. Kish   +6 more
semanticscholar   +1 more source

Psychosocial interventions for cocaine and psychostimulant amphetamines related disorders.

Cochrane Database of Systematic Reviews, 2015
W. P. Knapp, B. Soares, Michael Farrell, M. D. de Lima   +3 more
semanticscholar   +1 more source