Results 91 to 100 of about 40,355 (156)

Synthesis and Pharmacology of Ester Modified (+/-)-threo-Methylphenidate Analogs [PDF]

open access: yesarXiv, 2014
As part of a program to develop compounds with potential to treat cocaine abuse, eleven (+/-)-threo-methylphenidate (TMP; Ritalin) derivatives were synthesized and tested in rat striatal tissue preparations for inhibitory potency against [3H]WIN 35,428 binding (WIN) to the dopamine (DA) transporter, [3H]citalopram binding (CIT) to the serotonin ...
arxiv  

EASI Drugs in the Streets of Colombia: Modeling Heterogeneous and Endogenous Drug Preferences [PDF]

open access: yesarXiv
The response of illicit drug consumers to large-scale policy changes, such as legalization, is heavily mediated by their demand behavior. Since individual drug use is driven by many unobservable factors, accounting for unobserved heterogeneity is crucial for modeling demand and designing targeted public policies. This paper introduces a finite Gaussian
arxiv  

Hypocretin / Orexin Receptor 1 Knockdown in GABA or Dopamine Neurons in the Ventral Tegmental Area Differentially Impact Mesolimbic Dopamine and Motivation for Cocaine

open access: yesAddiction Neuroscience, 2023
The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-administration ...
Emily M. Black   +6 more
doaj  

Muon Imaging for Illicit Cargo Detection: A Simulation-Based Study [PDF]

open access: yesarXiv
This study evaluates the potential of muon tomography as a non-invasive technique for detecting concealed illicit drugs in cargo, based on detailed simulations performed using the GEANT4 toolkit. A combined analysis of muon scattering and absorption data was employed to enhance material discrimination, with a focus on realistic smuggling scenarios ...
arxiv  

Mirtazapine decreased cocaine-induced c-fos expression and dopamine release in rats

open access: yesFrontiers in Psychiatry
IntroductionChronic cocaine exposure induces an increase in dopamine release and an increase in the expression of the Fos protein in the rat striatum.
Susana Barbosa-Méndez   +1 more
doaj   +1 more source

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