Results 81 to 90 of about 163,677 (304)

Cocaine abuse : behavior, pharmacology, and clinical applications /

, 1998
Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of
Higgins, Stephen T., Katz, Jonathan L.
core  

Healing together: Results from a pilot trial of 3,4‐Methylenedioxymethamphetamine‐enhanced cognitive‐behavioral conjoint therapy for posttraumatic stress disorder

Journal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) disrupts individual well‐being and relationship health, particularly among veteran/military couples with heightened risks due to deployment, family reintegration, and traumatic stress. Although cognitive‐behavioral conjoint therapy (CBCT) and brief CBCT (bCBCT) have demonstrated strong efficacy in reducing ...
Leslie A. Morland, Chandra E. Khalifian, Dimitri Perivoliotis, Bettye Chargin, Al Alam, Tamara R. Wachsman, Dhakshin Ramanathan, Andrew W. Bismark, Christopher Stauffer, Anne C. Wagner, Abigail C. Angkaw, Kayla C. Knopp   +11 more
wiley   +1 more source

Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study

BMC Public Health
Background Increased cocaine supply has coincided with increased global cocaine use. In 2019 Ireland had one of the highest last-year rates of cocaine use in Europe.
Deirdre Mongan, Seán R. Millar, Anne Marie Carew, Cathy Kelleher, Antoinette Daly, Suzi Lyons, Brian Galvin, Bobby P. Smyth   +7 more
doaj   +1 more source

Plasma Cell Mucositis: A 20‐Year Retrospective Review at a Tertiary Center

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Plasma cell mucositis (PCM) is a rare, chronic inflammatory condition of mucosal surfaces that is likely underdiagnosed and underreported, with limited data on its clinical characteristics, extracavitary involvement, and treatment outcomes.
Miguel A. Aristizabal‐Torres, Jessi M. Larrinaga, Katherine Bodiford, Olayemi Sokumbi, Leila Tolaymat   +4 more
wiley   +1 more source

Reduced frontal brain volume in non-treatment seeking cocaine dependent individuals: exploring the role of impulsivity, depression and smoking

Frontiers in Human Neuroscience, 2014
In cocaine-dependent patients, grey matter (GM) volume reductions have been observed in the frontal lobes that are associated with duration of cocaine use.
Cleo Lina Crunelle, Cleo Lina Crunelle, Anne Marije eKaag, Guido eVan Wingen, Hanna E. van den Munkhof, Judith eHomberg, Liesbeth eReneman, Wim eVan Den Brink, Wim eVan Den Brink   +8 more
doaj   +1 more source

Functional Neurogenomics of Cocaine

, 2002
Dissertation prepared under the direction of Kent E. Vrana, Ph.D., Associate Professor of Physiology and Pharmacology and Director of Graduate Studies Chronic cocaine abuse causes altered neuronal gene expression, morphology, and physiology.
Freeman, Willard Morgan
core  

Chemical Ionization Mass Spectrometry: Fundamental Principles, Diverse Applications, and the Latest Technological Frontiers

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The review examines the evolution of chemical ionization mass spectrometry (CI‐MS), a technique developed in 1966 by Field and Munson. CI is a soft‐ionization method that produces more intense molecular ions with less fragmentation than electron ionization (EI).
Malvika Dutt, Adriana Arigò, Giorgio Famiglini, Pierangela Palma, Achille Cappiello   +4 more
wiley   +1 more source

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats

Scientific Reports
Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6).
Huimei Wei, Johnathan E. LeSaint, Zhenyu Jin, Chang-Guo Zhan, Fang Zheng   +4 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Corticostriatal cocaine-seeking ensembles are defined by differing gene expression from sucrose-seeking ensembles using a within-subject dual self-administration and seeking mouse model

Addiction Neuroscience
Recurrent cocaine seeking is a hallmark of cocaine use disorder. To develop therapeutic targets, it is critical to understand the neurobiological changes specific to cocaine-seeking in context with the seeking of non-drug rewards, e.g., sucrose.
Carl G. Litif, Levi T. Flom, Kathryn L. Sandum, Skylar L. Hodgins, Lucio Vaccaro, Jerry A. Stitzel, Nathan Ungerleider, Maria Constanza Mannino, Jason P. Gigley, Todd A. Schoborg, Ana-Clara Bobadilla   +10 more
doaj   +1 more source