Results 61 to 70 of about 163,677 (304)
Estimating Illicit Stimulant Drug Consumption in Luxembourg Using Wastewater‐Based Epidemiology
Drug Testing and Analysis, EarlyView.Wastewater‐based epidemiology provided nationwide estimates of illicit stimulant consumption in Luxembourg, revealing higher urban use, weekend increases in cocaine and MDMA, and cocaine as the dominant stimulant. The approach offers an objective complement to conventional drug surveillance for informing public health and policy.
Nadine Berndt +5 more
wiley +1 more source
Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics
Molecules, 2021 Cocaine toxicity has been a subject of study because cocaine is one of the most common and potent drugs of abuse. In the current study the effect of cocaine on human liver cancer cell line (HepG2) was assessed.
Adamantios Krokos +7 more
doaj +1 more source
Drug Testing and Analysis, EarlyView.Across 33 Anti‐Doping Organisations (ADOs), 85% reported experiencing at least one contamination‐claim case in 2024–2025, but only 36% operate a standardised process for handling such claims. Dietary supplements were the leading alleged contamination source (76% of ADOs), followed by food (42%) and pharmaceutical products, intimate contact, and other ...
Kristian Slíž +2 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani +6 more
wiley +1 more source
The Role of Nitrous Oxide (“Laughing Gas”) in DUID Cases and Its Impact on Driving Fitness
Drug Testing and Analysis, EarlyView.A total number of 39 cases of driving under the influence of nitrous oxide were investigated. Plasma concentrations of 0.22 to 17 mL/L (median:3.7 mL/L) were measured in blood samples withdrawn 38 to 144 min (median: 85 min) after control via Headspace‐GC–MS.
L. Lucuta +4 more
wiley +1 more source
Cocaine Production and Trafficking: What do we know? [PDF]
The main purpose of this chapter is to summarize the information currently available on cocaine production and trafficking. The chapter starts by describing the available data on cocaine production and trade, the collection methodologies, (if available ...
Daniel Mejía, Carlos Esteban Posada
core +2 more sources
Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. [PDF]
PLoS ONE, 2012 Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH
Marilyn E Carroll +9 more
doaj +1 more source
Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation
, 2017 Neuroinflammation plays a critical role in the development of reward-related behavior in cocaine self-administration rodents. Cocaine, one of most commonly abused drugs, has been shown to activate microglia both in vitro and in vivo.
Fang Niu (316587) +6 more
core +1 more source