Results 61 to 70 of about 188,136 (212)
Incubation of Cue-Induced Craving in Adults Addicted to Cocaine Measured by Electroencephalography
JAMA psychiatry, 2016 IMPORTANCE A common trigger for relapse in drug addiction is the experience of craving via exposure to cues previously associated with drug use. Preclinical studies have consistently demonstrated incubation of cue-induced drug-seeking during the initial ...
M. Parvaz +2 more
semanticscholar +1 more source
The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior
Frontiers in Behavioral Neuroscience, 2016 Social partners influence the likelihood of using drugs, developing a substance use disorder, and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of ...
Mark Andrew Smith +2 more
doaj +1 more source
Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics
Molecules, 2021 Cocaine toxicity has been a subject of study because cocaine is one of the most common and potent drugs of abuse. In the current study the effect of cocaine on human liver cancer cell line (HepG2) was assessed.
Adamantios Krokos +7 more
doaj +1 more source
Cocaine modulates locomotion behavior in C. elegans.
PLoS ONE, 2009 Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter).
Alex Ward +3 more
doaj +1 more source
High Impulsivity Predicts the Switch to Compulsive Cocaine Taking
Science, 2008 Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is ...
D. Belin +4 more
semanticscholar +1 more source
European Neuropsychopharmacology, 2015 Recent animal studies demonstrate that compulsive cocaine seeking strongly reduces prelimbic frontal cortex activity, while optogenetic stimulation of this brain area significantly inhibits compulsive cocaine seeking, providing a strong rationale for ...
A. Terraneo +5 more
semanticscholar +1 more source