Results 61 to 70 of about 160,082 (298)
Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. [PDF]
PLoS ONE, 2012 Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH
Marilyn E Carroll +9 more
doaj +1 more source
Human Carboxylesterase 2 in Cocaine Metabolism [PDF]
, 2021 Increased hydrolysis of cocaine to non-toxic compounds is a promising way to prevent cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid conversion in the body to the hydrolysis-resistant metabolite ...
Alexandra T.P., Carvalho +2 more
core +1 more source
Breaking point: Identifying the factors that predict suspension from school
British Educational Research Journal, EarlyView.Abstract School suspensions are associated with adverse educational and psychosocial outcomes, yet little is known about how structural disadvantage, relational factors, health behaviours, well‐being indicators and school‐level factors jointly predict suspension risk in England.
Stephanie Cahill +5 more
wiley +1 more source
Basic Pharmacological Mechanisms of Cocaine
, 1998 The chapter discusses the increasing dopaminergic activity of cocaine, by binding to the dopamine transporter and inhibiting dopamine uptake. The primary method by which dopamine is deactivated after its release into the synapse is also presented.
Sari Izenwasser, Izenwasser, Sari
core +1 more source
Criminal Behaviour and Mental Health, EarlyView.ABSTRACT Background Mental health courts divert individuals with serious mental illness away from imprisonment into community‐based treatment and supervision. Early research indicates that such treatment contracts can reduce recidivism and provide various other benefits. Aspects of eligibility for this diversion option are still under‐researched.
Steven Keener, Audrey Morrison
wiley +1 more source
Chemistry – A European Journal, EarlyView.Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen +7 more
wiley +1 more source
Cocaine modulates locomotion behavior in C. elegans.
PLoS ONE, 2009 Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter).
Alex Ward +3 more
doaj +1 more source
4141 Molecular Signatures of Cocaine Toxicity in Postmortem Human Brain and Neurons
Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: The goal of this project is to identify new therapeutic targets and biomarkers to treat or prevent cocaine toxicity by investigating proteomic, transcriptomic and epigenetic signatures of cocaine exposure in human subjects.
Emily Frances Mendez +6 more
doaj +1 more source