Results 41 to 50 of about 188,136 (212)
Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission
Addiction Neuroscience, 2022 Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse.
I. Pamela Alonso +4 more
doaj +1 more source
The importance of considering polysubstance use: lessons from cocaine research
Drug and Alcohol Dependence, 2018 Background: Polysubstance use (PSU) is prevalent among individuals with substance use disorders, but the vast majority of preclinical substance use research has focused on individual substances in isolation.
Yiyang Liu +4 more
semanticscholar +1 more source
Addictive Behaviors ReportsBackground: Craving is a core symptom of cocaine use disorders (CUD). Inducing craving in exposure to substance cues is of relevant interest for numerous clinical applications.
Thomas Lehoux +6 more
doaj +1 more source
In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Strong associations between cocaine and the environmental contexts where cocaine is administered are thought to drive relapse. The nucleus accumbens (NAc) encodes these cue–reward associations, and here we determined how cocaine alters the ...
E. Calipari +11 more
semanticscholar +1 more source
Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum
Cell Reports, 2020 Summary: Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic (VPGlu) neurons, and a subpopulation of GABAergic neurons co-express ...
Jasper A. Heinsbroek +6 more
doaj +1 more source
Scientific Reports, 2023 Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine to ...
Linyue Shang +5 more
doaj +1 more source
Vascular disease in cocaine addiction
Atherosclerosis, 2017 Cocaine, a powerful vasoconstrictor, induces immune responses including cytokine elevations. Chronic cocaine use is associated with functional brain impairments potentially mediated by vascular pathology. Although the Crack-Cocaine epidemic has declined,
K. Bachi +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi +7 more
doaj +1 more source
Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement
Science, 2007 Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and
J. Dalley +16 more
semanticscholar +1 more source