Results 31 to 40 of about 163,677 (304)
Silent Cocaine Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual.
Rachid El-Jaoudi +5 more
doaj
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]
PLoS ONE, 2008 Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
doaj +1 more source
Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission
Addiction Neuroscience, 2022 Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse.
I. Pamela Alonso +4 more
doaj +1 more source
Addictive Behaviors ReportsBackground: Craving is a core symptom of cocaine use disorders (CUD). Inducing craving in exposure to substance cues is of relevant interest for numerous clinical applications.
Thomas Lehoux +6 more
doaj +1 more source
Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum
Cell Reports, 2020 Summary: Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic (VPGlu) neurons, and a subpopulation of GABAergic neurons co-express ...
Jasper A. Heinsbroek +6 more
doaj +1 more source
Let it snow! let it snow! let it snow! Estimating cocaine production using a novel dataset based on reported seizures of laboratories [PDF]
, 2012 BackgroundData on the cocaine market appear inconsistent, as they tend to show declining prices vis-a-vis steady or increasing demand and a declining supply.
Rentocchini, Francesco +5 more
core +1 more source
Scientific Reports, 2023 Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine to ...
Linyue Shang +5 more
doaj +1 more source
Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes.
PLoS ONE, 2013 ObjectiveThe search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence ...
André Brooking Negrão +6 more
doaj +1 more source
Addiction Neuroscience, 2023 The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-administration ...
Emily M. Black +6 more
doaj +1 more source