Results 31 to 40 of about 188,136 (212)
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]
PLoS ONE, 2008 Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
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Frontiers in Neuroscience, 2022 Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas +3 more
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Nature Communications, 2018 Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction.
E. Calipari +9 more
semanticscholar +1 more source
Cocaine self-administration alters transcriptome-wide responses in the brain’s reward circuitry
Biological Psychiatry, 2018 BACKGROUND Global changes in gene expression underlying circuit and behavioral dysregulation associated with cocaine addiction remain incompletely understood.
D. Walker +21 more
semanticscholar +1 more source
Can ropinirole modulate reinforcing subjective effects of cocaine in humans?
Frontiers in Psychiatry, 2011 In this study we evaluated, by means of the Cocaine Rush Visual Analogue Scale (CRVAS), the impact of ropinirole on the expected rush induced by cocaine in a group of heroin addicts abusing cocaine; the self-reported reaction to the rush blockade (if ...
Angelo Giovanni Icro eMaremmani +8 more
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Synaptic mechanisms underlying persistent cocaine craving
Nature Reviews Neuroscience, 2016 Although it is challenging for individuals with cocaine addiction to achieve abstinence, the greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues associated with prior cocaine use.
M. Wolf
semanticscholar +1 more source
Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]
PLoS ONE, 2013 The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
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Associations amongst form of cocaine used (powder vs crack vs both) and HIV-related outcomes
Addictive Behaviors Reports, 2021 Introduction: Cocaine (including powder and crack) use is common among people with HIV (PWH). We identified socio-demographic and behavioral factors associated with cocaine use (overall and various forms) among PWH; we also examined differences in HIV ...
Yiyang Liu +4 more
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Neuropsychopharmacology, 2018 Novel molecular targets are needed to develop new medications for the treatment of cocaine addiction. Here we investigated a role for glucagon-like peptide-1 (GLP-1) receptors in the reinstatement of cocaine-seeking behavior, an animal model of relapse ...
N. Hernandez +6 more
semanticscholar +1 more source
Silent Cocaine Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual.
Rachid El-Jaoudi +5 more
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