Results 11 to 20 of about 112,229 (260)
Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
Translational Psychiatry, 2021 Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez +16 more
doaj +1 more source
The Cerebellum on Cocaine [PDF]
Frontiers in Systems Neuroscience, 2020 The traditional cerebellum's role has been linked to the high computational demands for sensorimotor control. However, several findings have pointed to its involvement in executive and emotional functions in the last decades. First in 2009 and then, in 2016, we raised why we should consider the cerebellum when thinking about drug addiction.
MIQUEL, MARTA +2 more
openaire +4 more sources
Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use.
PLoS ONE, 2020 The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching ...
David F Havlicek +6 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice. [PDF]
PLoS ONE, 2014 The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of ...
Jonathan S Miller +5 more
doaj +1 more source
Toxicology Reports, 2019 Crack cocaine smokers inhale, alongside with cocaine, its pyrolysis product, anhydroecgonine methyl ester (AEME). We have previously described AEME neurotoxic effect and its additive effect when co-incubated with cocaine.
Raphael Caio Tamborelli Garcia +6 more
doaj +1 more source
Addiction Neuroscience, 2023 Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increased cue-induced ...
Claire M. Corbett +2 more
doaj +1 more source
Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. [PDF]
PLoS ONE, 2014 Cocaine exposure during gestation causes protracted neurobehavioral changes consistent with a compromised glutamatergic system. Although cocaine profoundly disrupts glutamatergic neurotransmission and in utero cocaine exposure negatively affects ...
Kalindi Bakshi +5 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Jonathan eHollander +3 more
doaj +1 more source