Results 11 to 20 of about 188,136 (212)
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking
Science, 2020 More than a normal neurotransmitter The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack et al. found that, with cocaine exposure, there is an intracellular accumulation of dopamine in neurons of a brain region ...
Ashley E. Lepack +21 more
semanticscholar +1 more source
Heliyon, 2023 A single non-contingent dose of cocaine reinstates extinguished lever pressing behavior in rats trained to self-administer cocaine. This represents a model of relapse in cocaine use disorder and the number of lever presses has been the standard measure ...
Dakota B. Zinani +2 more
doaj +1 more source
Annals of Internal Medicine, 1992 Thank you for reading artificial neural networks. Maybe you have knowledge that, people have search numerous times for their favorite novels like this artificial neural networks, but end up in harmful downloads.
Anil K. Jain, J. Mao, K. Mohiuddin
semanticscholar +1 more source
Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
Translational Psychiatry, 2021 Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez +16 more
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Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use.
PLoS ONE, 2020 The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching ...
David F Havlicek +6 more
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The Cerebellum on Cocaine [PDF]
Frontiers in Systems Neuroscience, 2020 The traditional cerebellum's role has been linked to the high computational demands for sensorimotor control. However, several findings have pointed to its involvement in executive and emotional functions in the last decades. First in 2009 and then, in 2016, we raised why we should consider the cerebellum when thinking about drug addiction.
MIQUEL, MARTA +2 more
openaire +4 more sources
MMWR. Morbidity and mortality weekly report, 2019 In 2016, a total of 63,632 persons died from drug overdoses in the United States (1). Drug overdose deaths involving cocaine, psychostimulants with abuse potential (psychostimulants), or both substances combined increased 42.4% from 12,122 in 2015 to 17 ...
Mbabazi Kariisa +4 more
semanticscholar +1 more source
The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice. [PDF]
PLoS ONE, 2014 The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of ...
Jonathan S Miller +5 more
doaj +1 more source
Toxicology Reports, 2019 Crack cocaine smokers inhale, alongside with cocaine, its pyrolysis product, anhydroecgonine methyl ester (AEME). We have previously described AEME neurotoxic effect and its additive effect when co-incubated with cocaine.
Raphael Caio Tamborelli Garcia +6 more
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